| Weight | 341.451 g/mol |
|---|---|
| Formula | C21H27NO3 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 11 |
propafenone
Rythmol · Propafenone Hydrochloride · Nistaken
107381-31-7, 107300-59-4, 54063-53-5, 107381-32-8
Score:
#139 in Biochemistry
,
#597 in Biology
,
#635 in Chemistry
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- Polymorphism of propafenone metabolism and disposition in man: clinical and pharmacokinetic consequences. (Circulation, 1987)
- Propafenone versus sotalol for suppression of recurrent symptomatic atrial fibrillation (American Journal of Cardiology, 1993)
- Effects of oral propafenone administration before electrical cardioversion of chronic atrial fibrillation: a placebo-controlled study. (Journal of the American College of Cardiology, 1996)
- Clinical pharmacology of propafenone. (Circulation, 1983)
- K+ channel blocking actions of flecainide compared with those of propafenone and quinidine in adult rat ventricular myocytes. (Journal of Pharmacology and Experimental Therapeutics, 1994)
- Conversion of recent-onset atrial fibrillation by a single oral loading dose of propafenone or flecainide. (American Journal of Cardiology, 1994)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Rythmol
- Propafenone Hydrochloride
- Nistaken
- SA 79
- Jutanorm
- SA-79
- Rytmonorm
- Arythmol
- Apo-Propafenone
- Fenoprain
- Rytmogenat
- Propafenone, (+-)-Isomer
- Pintoform
- Propafenon AL
- Rytmo-Puren
- Propafenone Hydrochloride, (S)-Isomer
- Propafenon Minden
- Propafenone, (S)-Isomer
- Propafenone Hydrochloride, (R)-Isomer
- SA79
- Norfenon
- Propafenon Hexal
- Prolecofen
- Propafenone, (R)-Isomer
- Baxarytmon
- Propamerck
- Cuxafenon
-
SMILESCCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
-
InChIKeyJWHAUXFOSRPERK-UHFFFAOYSA-N
- Pubchem - propafenone
- Wikipedia - propafenone
Propafenone ( proh-PAF-i-nohn; brand name Rythmol SR or Rytmonorm) is a class 1C anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.
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Alternate Names
Estimated Properties
| Boiling Point | 419.49 C | EPA T.E.S.T. |
|---|---|---|
| Density | 1.1 g/cm3 | EPA T.E.S.T. |
| Flash Point | 263.24 C | EPA T.E.S.T. |
| Water Solubility | 17.44 mg/L | EPA T.E.S.T. |
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Synthesis
Reactant
+
(2-Chloroethyl)benzene
(Grignard carbonyl)
benzene
+
Reactant
(Friedel-Crafts alkylation)
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