| Weight | 427.545 g/mol |
|---|---|
| Formula | C24H33N3O4 |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 9 |
RANOLAZINE (95635-55-5, 142387-99-3)
Score:
#252 in Neuroscience
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#317 in Biochemistry
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#1157 in Biology
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#1320 in Chemistry
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- Electrophysiological Effects of Ranolazine, a Novel Antianginal Agent With Antiarrhythmic Properties (Circulation, 2004)
- Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial. (JAMA, 2004)
- Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina. (Journal of the American College of Cardiology, 2004)
- Effects of Ranolazine on Recurrent Cardiovascular Events in Patients With NonST-Elevation Acute Coronary Syndromes: The MERLIN-TIMI 36 Randomized Trial (JAMA, 2007)
- Effect of Ranolazine, an Antianginal Agent With Novel Electrophysiological Properties, on the Incidence of Arrhythmias in Patients With NonST-SegmentElevation Acute Coronary Syndrome Results From the Metabolic Efficiency With Ranolazine for Less Ischemia in NonST-Elevation Acute Coronary SyndromeThrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) Randomized Controlled Trial (Circulation, 2007)
- Atrium-Selective Sodium Channel Block as a Strategy for Suppression of Atrial Fibrillation: Differences in Sodium Channel Inactivation Between Atria and Ventricles and the Role of Ranolazine (Circulation, 2007)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O
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InChIKeyXKLMZUWKNUAPSZ-UHFFFAOYSA-N
- Pubchem - RANOLAZINE
- Wikipedia - ranolazine
Ranolazine, sold under the trade name Ranexa by Gilead Sciences, is a drug to treat angina that was first approved in 2006.
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Synthesis
Reactant
+
5294-61-1
(Chan-Lam coupling reaction)
Reactant
+
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(Schotten-Baumann amide from acid)
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