| Weight | 552.546 g/mol |
|---|---|
| Formula | C31H35Cl2N3O2 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 9 |
Saredutant (142001-63-6)
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- The effect of the NK2 tachykinin receptor antagonist SR 48968 (saredutant) on neurokinin A-induced bronchoconstriction in asthmatics (European Respiratory Journal, 1998)
- Additional evidence for anxiolytic- and antidepressant-like activities of saredutant (SR48968), an antagonist at the neurokinin-2 receptor in various rodent-models (Pharmacology, Biochemistry and Behavior, 2008)
- Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditions. (Pharmacology, Biochemistry and Behavior, 2008)
- Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression (Pharmacology, Biochemistry and Behavior, 2010)
- Behavioural and neurochemical changes induced by stress-related conditions are counteracted by the neurokinin-2 receptor antagonist saredutant (The International Journal of Neuropsychopharmacology, 2013)
- Use of saredutant for the treatment of adaptation, bipolar, and dysthymic disorders (2000)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(=O)NC1(CCN(CC1)CCC(CN(C)C(=O)C2=CC=CC=C2)C3=CC(=C(C=C3)Cl)Cl)C4=CC=CC=C4
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InChIKeyPGKXDIMONUAMFR-UHFFFAOYSA-N
- Pubchem - Saredutant
- Wikipedia - saredutant
Saredutant (SR-48,968) is a drug that acts as a NK2 receptor antagonist. It was under development by Sanofi-Aventis as a novel antidepressant and anxiolytic and made it to phase III clinical trials. However, in May 2009, Sanofi-Aventis published its quarterly results and announced the cessation of 14 research/development projects, among which was saredutant for the treatment of major depressive disorder.
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