| Weight | 464.831 g/mol |
|---|---|
| Formula | C21H16ClF3N4O3 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 5 |
Sorafenib (284461-73-0)
Score:
#5 in Molecular and cellular biology
,
#205 in Biochemistry
,
#911 in Chemistry
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- Sorafenib in Advanced Hepatocellular Carcinoma (The New England Journal of Medicine, 2008)
- Sorafenib in Advanced Clear-Cell Renal-Cell Carcinoma (The New England Journal of Medicine, 2007)
- Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial (Lancet Oncology, 2009)
- Discovery and development of sorafenib: a multikinase inhibitor for treating cancer (Nature Reviews Drug Discovery, 2006)
- Phase II Placebo-Controlled Randomized Discontinuation Trial of Sorafenib in Patients With Metastatic Renal Cell Carcinoma (Journal of Clinical Oncology, 2006)
- Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial (The Lancet, 2011)
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SMILESCNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
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- Pubchem - Sorafenib
- Wikipedia - sorafenib
Sorafenib (co-developed and co-marketed by Bayer and Onyx Pharmaceuticals as Nexavar), is a kinase inhibitor drug approved for the treatment of primary kidney cancer (advanced renal cell carcinoma), advanced primary liver cancer (hepatocellular carcinoma), and radioactive iodine resistant advanced thyroid carcinoma.
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Reactant
+
4-(4-Aminophenoxy)-N-methylpicolinamide
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Sorafenib
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