| Weight | 637.036 g/mol |
|---|---|
| Formula | C28H24ClF3N4O6S |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 4 |
| Aromatic Rings | 4 |
| Rotatable Bonds | 6 |
Sorafenib tosylate (475207-59-1)
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- Bevacizumab, sorafenib tosylate, sunitinib and temsirolimus for renal cell carcinoma: a systematic review and economic evaluation (Health Technology Assessment, 2010)
- In Vitro to In Vivo Comparison of the Substrate Characteristics of Sorafenib Tosylate toward P-Glycoprotein (Drug Metabolism and Disposition, 2010)
- Sorafenib tosylate and paclitaxel induce anti-angiogenic, anti-tumour and anti-resorptive effects in experimental breast cancer bone metastases (European Journal of Cancer, 2011)
- A Patient with Advanced Hepatocellular Carcinoma Treated with Sorafenib Tosylate Showed Massive Tumor Lysis with Avoidance of Tumor Lysis syndrome (Internal Medicine, 2010)
- A large-scale prospective registration study of the safety and efficacy of sorafenib tosylate in unresectable or metastatic renal cell carcinoma in Japan: results of over 3200 consecutive cases in post-marketing all-patient surveillance (Japanese Journal of Clinical Oncology, 2015)
- Sorafenib tosylate in advanced kidney cancer: past, present and future. (Anti-Cancer Drugs, 2009)
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SMILESCC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
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- Pubchem - Sorafenib tosylate
- Wikipedia - sorafenib tosylate
Sorafenib (co-developed and co-marketed by Bayer and Onyx Pharmaceuticals as Nexavar), is a kinase inhibitor drug approved for the treatment of primary kidney cancer (advanced renal cell carcinoma), advanced primary liver cancer (hepatocellular carcinoma), and radioactive iodine resistant advanced thyroid carcinoma.
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4-(4-Aminophenoxy)-N-methylpicolinamide
(Schotten-Baumann amide from acid)
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Sorafenib tosylate
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