Weight | 440.606 g/mol |
---|---|
Formula | C22H36N2O5S |
Hydrogen Acceptors | 5 |
Hydrogen Donors | 3 |
Aromatic Rings | 1 |
Rotatable Bonds | 14 |
tirofiban (144494-65-5)
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#79 in Neurology
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#399 in Neuroscience
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#1805 in Biology
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#2151 in Chemistry
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- Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban. (The New England Journal of Medicine, 2001)
- Effects of Platelet Glycoprotein IIb/IIIa Blockade With Tirofiban on Adverse Cardiac Events in Patients With Unstable Angina or Acute Myocardial Infarction Undergoing Coronary Angioplasty (Circulation, 1997)
- Comparison of two platelet glycoprotein IIb/IIIa inhibitors, tirofiban and abciximab, for the prevention of ischemic events with percutaneous coronary revascularization. (The New England Journal of Medicine, 2001)
- Troponin concentrations for stratification of patients with acute coronary syndromes in relation to therapeutic efficacy of tirofiban (The Lancet, 1999)
- Prehospital initiation of tirofiban in patients with ST-elevation myocardial infarction undergoing primary angioplasty (On-TIME 2): a multicentre, double-blind, randomised controlled trial. (The Lancet, 2008)
- Tirofiban and sirolimus-eluting stent vs abciximab and bare-metal stent for acute myocardial infarction: A randomized trial (JAMA, 2005)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCCCS(=O)(=O)NC(CC1=CC=C(C=C1)OCCCCC2CCNCC2)C(=O)O
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- Pubchem - tirofiban
- Wikipedia - tirofiban hydrochloride
Tirofiban (INN, trade name Aggrastat) is an antiplatelet drug. It belongs to a class of antiplatelet named glycoprotein IIb/IIIa inhibitors. Tirofiban is a small molecule inhibitor of the protein-protein interaction between fibrinogen and the platelet integrin receptor GP IIb/IIIa and is the first drug candidate whose origins can be traced to a pharmacophore-based virtual screening lead.
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