| Weight | 421.453 g/mol |
|---|---|
| Formula | C23H23N3O5 |
| Hydrogen Acceptors | 8 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 3 |
topotecan (119413-54-6, 123948-87-8)
Score:
#297 in Biochemistry
,
#1104 in Biology
,
#1243 in Chemistry
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- Recurrent Epithelial Ovarian Carcinoma: A Randomized Phase III Study of Pegylated Liposomal Doxorubicin Versus Topotecan (Journal of Clinical Oncology, 2001)
- Topotecan versus cyclophosphamide, doxorubicin, and vincristine for the treatment of recurrent small-cell lung cancer. (Journal of Clinical Oncology, 1999)
- Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian cancer. (Journal of Clinical Oncology, 1997)
- Role of Breast Cancer Resistance Protein in the Bioavailability and Fetal Penetration of Topotecan (Journal of the National Cancer Institute, 2000)
- Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: a rational approach to clinical protocol design. (Journal of the National Cancer Institute, 1994)
- Overexpression of the BCRP/MXR/ABCP Gene in a Topotecan-selected Ovarian Tumor Cell Line (Cancer Research, 1999)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=C(C5=C4)CN(C)C)O)O
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InChIKeyUCFGDBYHRUNTLO-UHFFFAOYSA-N
- Pubchem - topotecan
- Wikipedia - topotecan
Topotecan (trade name Hycamtin) is a chemotherapeutic agent that is a topoisomerase inhibitor. It is a synthetic, water-soluble analog of the natural chemical compound camptothecin. It is used in the form of its hydrochloride salt to treat ovarian cancer, lung cancer and other cancer types.
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