| Weight | 370.314 g/mol |
|---|---|
| Formula | C15H18N2O9 |
| Hydrogen Acceptors | 10 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 5 |
Uridine triacetate (4105-38-8)
2',3',5'-tri-O-acetyluridine · triacetyluridine
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- Functionalisation including fluorination of caffeine, guanosine tetraacetate, and uridine triacetate using electrochemical oxidation (Tetrahedron Letters, 1994)
- Triacetyluridine (TAU) Decreases Depressive Symptoms and Increases Brain pH in Bipolar Patients (Experimental and Clinical Psychopharmacology, 2008)
- Neuroprotective effects of oral administration of triacetyluridine against MPTP neurotoxicity. (Neuromolecular Medicine, 2004)
- 5-Fluorouracil dose escalation enabled with PN401 (triacetyluridine): toxicity reduction and increased antitumor activity in mice (Cancer Chemotherapy and Pharmacology, 2006)
- Use of uridine triacetate for the management of fluorouracil overdose (American Journal of Health-system Pharmacy, 2011)
- Enhanced Uridine Bioavailability Following Administration of a Triacetyluridine-Rich Nutritional Supplement (PLOS ONE, 2011)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - 2',3',5'-tri-O-acetyluridine
- triacetyluridine
-
SMILESCC(=O)OCC1C(C(C(O1)N2C=CC(=O)NC2=O)OC(=O)C)OC(=O)C
-
InChIKeyAUFUWRKPQLGTGF-UHFFFAOYSA-N
- Pubchem - Uridine triacetate
- Wikipedia - uridine triacetate
Uridine triacetate (INN), formerly known as vistonuridine, is an orally active tri-acetylated prodrug of uridine used: in the treatment of hereditary orotic aciduria (brand name Xuriden ZOOR--den); to treat patients following an overdose of chemotherapy drugs 5-fluorouracil (5-FU) or capecitabine regardless of the presence of symptoms, or who exhibit early-onset, severe or life-threatening toxicity affecting the cardiac or central nervous system, and/or early-onset, unusually severe adverse reactions (e.g., gastrointestinal toxicity and/or neutropenia) within 96 hours following the end of fluorouracil or capecitabine administration (brand name Vistogard). Uridine triacetate was developed, manufactured and distributed by Wellstat Therapeutics and it is marketed in USA by BTG. Also, It was granted breakthrough therapy designation by FDA in 2015.
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