| Weight | 435.528 g/mol |
|---|---|
| Formula | C24H29N5O3 |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 10 |
valsartan (137862-53-4)
Score:
#53 in Biochemistry
,
#305 in Chemistry
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- A RANDOMIZED TRIAL OF THE ANGIOTENSIN-RECEPTOR BLOCKER VALSARTAN IN CHRONIC HEART FAILURE (The New England Journal of Medicine, 2001)
- Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial (The Lancet, 2004)
- Valsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or Both (The New England Journal of Medicine, 2003)
- Changes in Brain Natriuretic Peptide and Norepinephrine Over Time and Mortality and Morbidity in the Valsartan Heart Failure Trial (Val-HeFT) (Circulation, 2003)
- Microalbuminuria Reduction With Valsartan in Patients With Type 2 Diabetes Mellitus A Blood PressureIndependent Effect (Circulation, 2002)
- Effect of valsartan on the incidence of diabetes and cardiovascular events (The New England Journal of Medicine, 2010)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(C(C)C)C(=O)O
-
InChIKeyACWBQPMHZXGDFX-UHFFFAOYSA-N
- Pubchem - valsartan
- Wikipedia - valsartan
Valsartan (trade name Diovan) is mainly used for treatment of high blood pressure, congestive heart failure, and to increase the chances of living longer after a heart attack. It is an angiotensin II receptor antagonist (commonly called an ARB, or angiotensin receptor blocker), that is selective for the type I (AT1) angiotensin receptor.
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Synthesis
5-(2-Bromophenyl)-1H-tetrazole
+
Reactant
(Stille)
Reactant
+
5-(2-chlorophenyl)-1H-tetrazole
(Suzuki)
Reactant
+
5-(2-chlorophenyl)-1H-tetrazole
(Decarboxylative coupling)
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valsartan
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