| Weight | 428.437 g/mol |
|---|---|
| Formula | C23H24O8 |
| Hydrogen Acceptors | 8 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 3 |
wortmannin (19545-26-7)
Score:
#40 in Molecular and cellular biology
,
#1243 in Biochemistry
,
#3083 in Biology
,
#3854 in Chemistry
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- Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses (Biochemical Journal, 1993)
- Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine (Molecular Cell, 2000)
- Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin. (Journal of Biological Chemistry, 1994)
- Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. (Journal of Biological Chemistry, 1993)
- Insulin-stimulated Production of Nitric Oxide Is Inhibited by Wortmannin Direct Measurement in Vascular Endothelial Cells (Journal of Clinical Investigation, 1996)
- Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. (The EMBO Journal, 1996)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C5=COC(=C54)C3=O)COC)C)C
-
InChIKeyQDLHCMPXEPAAMD-UHFFFAOYSA-N
- Pubchem - wortmannin
- Wikipedia - LSM-1788
Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces wortmannii, is a non-specific, covalent inhibitor of phosphoinositide 3-kinases (PI3Ks). It has an in vitro inhibitory concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor. It displays a similar potency in vitro for the class I, II, and III PI3K members although it can also inhibit other PI3K-related enzymes such as mTOR, DNA-PKcs, some phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) at high concentrations , Wortmannin has also been reported to inhibit members of the polo-like kinase family with IC50 in the same range as for PI3K.
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