| Weight | 281.425 g/mol |
|---|---|
| Formula | C14H23N3OS |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 7 |
XANOMELINE (131986-45-3)
Score:
#1082 in Neuroscience
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#4714 in Biology
,
#5992 in Chemistry
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- Effects of Xanomeline, a Selective Muscarinic Receptor Agonist, on Cognitive Function and Behavioral Symptoms in Alzheimer Disease (JAMA Neurology, 1997)
- Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia (American Journal of Psychiatry, 2008)
- Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors. (Journal of Pharmacology and Experimental Therapeutics, 1994)
- Xanomeline, an M1/M4 preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice (Schizophrenia Research, 2000)
- Xanomeline and the Antipsychotic Potential of Muscarinic Receptor Subtype Selective Agonists (Cns Drug Reviews, 2006)
- The Muscarinic Receptor Agonist Xanomeline Has an Antipsychotic-Like Profile in the Rat (Journal of Pharmacology and Experimental Therapeutics, 2001)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCCCCCOC1=NSN=C1C2=CCCN(C2)C
-
InChIKeyJOLJIIDDOBNFHW-UHFFFAOYSA-N
- Pubchem - XANOMELINE
- Wikipedia - xanomeline
Xanomeline (LY-246,708; Lumeron, Memcor) is a muscarinic acetylcholine receptor agonist with reasonable selectivity for the M1 and M4 subtypes, though it is also known to act as a M5 receptor antagonist. It has been studied for the treatment of both Alzheimer's disease and schizophrenia, particularly the cognitive and negative symptoms, although gastrointestinal side effects led to a high drop-out rate in clinical trials. Despite this, xanomeline has been shown to have reasonable efficacy for the treatment of schizophrenia symptoms, and one recent human study found robust improvements in verbal learning and short-term memory associated with xanomeline treatment.
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