| Weight | 603.75 g/mol |
|---|---|
| Formula | C30H53NO11 |
| Hydrogen Acceptors | 12 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 32 |
Benzonatate (104-31-4)
Tessalon
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- Benzonatate for opioid-resistant cough in advanced cancer. (Palliative Medicine, 1998)
- Studies on the endoanesthetic effects of lidocaine and benzonatate on non-medullated nerve endings in the left ventricle (Acta Physiologica Scandinavica, 1981)
- Inhibition of cough-reflex sensitivity by benzonatate and guaifenesin in acute viral cough. (Respiratory Medicine, 2009)
- Two fatalities resulting from Tessalon (benzonatate). (Veterinary and Human Toxicology, 1986)
- New effect mechanism of the antitussive drug tessalon (Schweizerische Medizinische Wochenschrift, 1956)
- Zur Frage der Receptorspezifitt endoanaesthetischer Wirkungen am Beispiel des Benzononatin (Tessalon) (Naunyn-schmiedebergs Archives of Pharmacology, 1963)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Tessalon
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SMILESCCCCNC1=CC=C(C=C1)C(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOC
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InChIKeyMAFMQEKGGFWBAB-UHFFFAOYSA-N
- Pubchem - Benzonatate
- Wikipedia - benzonatate
Benzonatatemarketed under the trade names Tessalon, Tessalon Perles, and Zonatussis a non-narcotic oral cough suppressant, or antitussive, with effects that last from six to eight hours. Since it is not an opioid, benzonatate is not as prone to abuse like some other cough medications such as codeine. Benzonatate was approved by the U.S.
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Synthesis
Octaethylene glycol monomethyl ether
+
Reactant
(Williamson ether)
4-(Butylamino)benzoic acid
+
Reactant
(Ester from carboxilic acid(SN2))
Reactant
+
1-Chlorobutane
(Alkylation of primary amines)
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