| Weight | 380.871 g/mol |
|---|---|
| Formula | C23H21ClO3 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 6 |
chlorotrianisene (569-57-3)
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- EFFECTS OF SYNTHETIC ORAL OESTROGENS IN NORMAL MEN AND PATIENTS WITH PROSTATIC CARCINOMA: LACK OF GONADOTROPHIN SUPPRESSION BY CHLOROTRIANISENE (Clinical Endocrinology, 1973)
- Preliminary Report on the Clinical Use of Tace (Chlorotrianisene) in Treatment of Prostatic Carcinoma (The Journal of Urology, 1951)
- Increased inhibition of hepatic uroporphyrinogen decarboxylase by hexachlorobenzene in male rats given the oestrogenic drugs diethylstilboestrol and chlorotrianisene. (Biochemical Pharmacology, 1981)
- EFFECT OF BROMOCRIPTINE AND CHLOROTRIANISENE ON TNHIBITION OF LACTATION AND SERUM PROLACTIN A COMPARATIVE DOUBLEBLIND STUDY (British Journal of Obstetrics and Gynaecology, 1975)
- Differential responses of pituitary kallikrein and prolactin to tamoxifen and chlorotrianisene (Molecular and Cellular Endocrinology, 1989)
- Inactivation of the uterine estrogen receptor binding of estradiol during P-450 catalyzed metabolism of chlorotrianisene (TACE): Speculation that TACE antiestrogenic activity involves covalent binding to the estrogen receptor (FEBS Letters, 1990)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCOC1=CC=C(C=C1)C(=C(C2=CC=C(C=C2)OC)Cl)C3=CC=C(C=C3)OC
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InChIKeyBFPSDSIWYFKGBC-UHFFFAOYSA-N
- Pubchem - chlorotrianisene
- Wikipedia - chlorotrianisene
Chlorotrianisene (INN, USAN, BAN; brand names Tace, Estregur, Anisene, Clorotrisin, Merbentyl, Triagen, many others; also known as CTA; tri-p-anisylchloroethylene, TACE, or tris(p-methoxyphenyl)chloroethylene) is a synthetic nonsteroidal estrogen of the triphenylethylene group which was formerly used for the treatment of menopausal symptoms, estrogen deficiency, and prostate cancer before being discontinued. It was approved in the United States as TACE in 1952, and was introduced throughout Europe subsequently. CTA was the first estrogenic compound of the triphenylethylene series to be introduced.
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