| Weight | 563.654 g/mol |
|---|---|
| Formula | C34H33N3O5 |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 5 |
| Rotatable Bonds | 8 |
Elacridar (143664-11-3)
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- Simultaneous delivery of doxorubicin and GG918 (Elacridar) by new polymer-lipid hybrid nanoparticles (PLN) for enhanced treatment of multidrug-resistant breast cancer. (Journal of Controlled Release, 2006)
- Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment. (Clinical Cancer Research, 2009)
- Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration. (International Journal of Cancer, 2012)
- A Phase I, Randomized, Open-Label, Parallel-Cohort, Dose-Finding Study of Elacridar (GF120918) and Oral Topotecan in Cancer Patients (Clinical Cancer Research, 2007)
- Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[11C]verapamil PET (European Journal of Nuclear Medicine and Molecular Imaging, 2010)
- Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice. (Journal of Cancer Research and Clinical Oncology, 2008)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCOC1=CC=CC2=C1NC3=C(C2=O)C=CC=C3C(=O)NC4=CC=C(C=C4)CCN5CCC6=CC(=C(C=C6C5)OC)OC
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InChIKeyOSFCMRGOZNQUSW-UHFFFAOYSA-N
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