| Weight | 318.501 g/mol |
|---|---|
| Formula | C21H34O2 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 1 |
Epipregnanolone (4406-35-3, 128-21-2)
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- Differential antagonism by epipregnanolone of alphaxalone and pregnanolone potentiation of [3H]flunitrazepam binding suggests more than one class of binding site for steroids at GABAA receptors (Neuropharmacology, 1993)
- Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats (Pharmacology, Biochemistry and Behavior, 2005)
- Effect of epipregnanolone and pregnenolone sulfate on chronic tolerance to ethanol (Pharmacology, Biochemistry and Behavior, 2000)
- Epipregnanolone acts as a partial agonist on a common neurosteroid modulatory site of the GABAA receptor complex in avian CNS (Neurochemical Research, 1997)
- Syntheses of 19-[O-(carboxymethyl)oxime] haptens of epipregnanolone and pregnanolone (Steroids, 2006)
- Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone (Psychopharmacology, 2014)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(=O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C
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InChIKeyAURFZBICLPNKBZ-UHFFFAOYSA-N
- Pubchem - Epipregnanolone
- Wikipedia - epipregnanolone
Epipregnanolone, also known as 3-hydroxy-5-pregnan-20-one or 3,5-tetrahydroprogesterone (3,5-THP), is an endogenous neurosteroid. It acts as a negative allosteric modulator of the GABAA receptor and reverses the effects of potentiators like allopregnanolone. Epipregnanolone is biosynthesized from progesterone by the actions of 5-reductase and 3-hydroxysteroid dehydrogenase, with 5-dihydroprogesterone as the intermediate in this two-step transformation.
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Epipregnanolone
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