| Weight | 393.443 g/mol |
|---|---|
| Formula | C22H23N3O4 |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 10 |
Erlotinib (183321-74-6)
Score:
#172 in Biochemistry
,
#724 in Biology
,
#784 in Chemistry
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- Erlotinib in Previously Treated NonSmall-Cell Lung Cancer (The New England Journal of Medicine, 2005)
- EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. (Proceedings of the National Academy of Sciences of the United States of America, 2004)
- Erlotinib Plus Gemcitabine Compared With Gemcitabine Alone in Patients With Advanced Pancreatic Cancer: A Phase III Trial of the National Cancer Institute of Canada Clinical Trials Group (Journal of Clinical Oncology, 2005)
- Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain (PLOS Medicine, 2005)
- Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial (Lancet Oncology, 2012)
- Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study (Lancet Oncology, 2011)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
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- Pubchem - Erlotinib
- Wikipedia - erlotinib
Erlotinib hydrochloride (trade name Tarceva) is a drug used to treat non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer. It is a receptor tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR). It is marketed in the United States by Genentech and OSI Pharmaceuticals and elsewhere by Roche.
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Estimated Properties
| Boiling Point | 498.79 C | EPA T.E.S.T. |
|---|---|---|
| Density | 1.23 g/cm3 | EPA T.E.S.T. |
| Flash Point | 282.76 C | EPA T.E.S.T. |
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Erlotinib
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