| Weight | 332.528 g/mol |
|---|---|
| Formula | C22H36O2 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 1 |
GANAXOLONE (38398-32-2)
Score:
#192 in Neurology
,
#854 in Neuroscience
,
#3746 in Biology
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- Characterization of the Anticonvulsant Properties of Ganaxolone (CCD 1042; 3a-Hydroxy-3b-methyl-5a-pregnan- 20-one), a Selective, High-Affinity, Steroid Modulator of the g-Aminobutyric Acid A Receptor (Journal of Pharmacology and Experimental Therapeutics, 1997)
- Chronic Treatment with the Neuroactive Steroid Ganaxolone in the Rat Induces Anticonvulsant Tolerance to Diazepam but Not to Itself (Journal of Pharmacology and Experimental Therapeutics, 2000)
- Enhanced Anticonvulsant Activity of Ganaxolone after Neurosteroid Withdrawal in a Rat Model of Catamenial Epilepsy (Journal of Pharmacology and Experimental Therapeutics, 2000)
- Initial Human Experience with Ganaxolone, a Neuroactive Steroid with Antiepileptic Activity (Epilepsia, 1997)
- Ganaxolone for treating intractable infantile spasms: a multicenter, open-label, add-on trial (Epilepsy Research, 2000)
- Assessment of Ganaxolone's Anticonvulsant Activity Using a Randomized, DoubleBlind, Presurgical Trial Design (Epilepsia, 2000)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(=O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)(C)O)C)C
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InChIKeyPGTVWKLGGCQMBR-UHFFFAOYSA-N
- Pubchem - GANAXOLONE
- Wikipedia - ganaxolone
Ganaxolone is an experimental CNS-selective GABAA modulator that is under development by Marinus Pharmaceuticals as an anxiolytic and anticonvulsant agent. Ganaxolone has been shown to protect against seizures in animal models, and to act a positive allosteric modulator of the GABAA receptor. Ganaxolone is being investigated for potential medical use in the treatment of epilepsy.
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