| Weight | 359.474 g/mol |
|---|---|
| Formula | C19H29N5O2 |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 6 |
Gepirone (83928-76-1)
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- Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain. (Synapse, 1987)
- Serotonergic mechanisms in the behavioral effects of buspirone and gepirone (Pharmacology, Biochemistry and Behavior, 1986)
- Acute and chronic effects of gepirone and fluoxetine in rats tested in the elevated plus-maze: an ethological analysis. (Pharmacology, Biochemistry and Behavior, 2000)
- 5-hydroxytryptamine1A receptor-mediated effects of buspirone, gepirone and ipsapirone (Pharmacology, Biochemistry and Behavior, 1988)
- Anxiolytic effects of buspirone and gepirone in the fear-potentiated startle paradigm (Psychopharmacology, 1988)
- Effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by 8-OH-DPAT (Psychopharmacology, 1987)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1(CC(=O)N(C(=O)C1)CCCCN2CCN(CC2)C3=NC=CC=N3)C
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InChIKeyQOIGKGMMAGJZNZ-UHFFFAOYSA-N
- Pubchem - Gepirone
- Wikipedia - gepirone
Gepirone is an antidepressant and anxiolytic drug of the azapirone group that was synthesized by Bristol-Myers Squibb in 1986 and has been under development for the treatment of depression but has yet to be marketed. It has been under development in the U.S. in an extended release form (referred to as gepirone ER), but despite completing phase III clinical trials and demonstrating efficacy, it has been rejected multiple times by the Food and Drug Administration (FDA) during the drug approval process.
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Gepirone
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