guanfacine hydrochloride (29110-48-3)

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Suppliers

• Sigma-Aldrich - guanfacine hydrochloride
  46.00 - 271.95 USD
• Fisher Scientific - Search for guanfacine hydrochloride
• TCI - guanfacine hydrochloride
  110.00 - 715.00 USD

Most-cited Publications

• A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder. (American Journal of Psychiatry, 2001)
• The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes (The Journal of Neuroscience, 1988)
• An Open Trial of Guanfacine in the Treatment of Attention-Deficit Hyperactivity Disorder (Journal of the American Academy of Child and Adolescent Psychiatry, 1995)
• A Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine Extended Release in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder (Pediatrics, 2008)
• Guanfacine Treatment of Comorbid Attention-Deficit Hyperactivity Disorder and Tourette's Syndrome: Preliminary Clinical Experience (Journal of the American Academy of Child and Adolescent Psychiatry, 1995)
• The alpha 2-adrenergic agonists clonidine and guanfacine produce tonic and phasic block of conduction in rat sciatic nerve fibers. (Anesthesia & Analgesia, 1993)

Areas of Application

Safety

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Trends

Alternate Names

• Guanfacine
• Tenex
• Guanfacine Monohydrochloride
• BS100141
• BS 100 141
• Estulic
• Lon798
• BS-100-141
• SMILES
  C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl.Cl
• InChIKey
  DGFYECXYGUIODH-UHFFFAOYSA-N

External Links

• Pubchem - guanfacine hydrochloride
• Wikipedia - guanfacine hydrochloride
  Guanfacine (trade names Estulic, Tenex, and, in extended release form, Intuniv) is a sympatholytic drug used to treat hypertension and attention deficit hyperactivity disorder (ADHD). It is a selective 2A receptor agonist.

Synthesis

urea  +  2-(2,6-dichlorophenyl)acetamide (Imine formation from aldehyde)

1,3-DICHLOROBENZENE  +  Chloroacetylguanidine (Friedel-Crafts alkylation)

Reactant  +  guanidine (Schotten-Baumann amide from acid)

Synthesis of guanfacine hydrochloride ›

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guanfacine hydrochloride

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