| Weight | 911.667 g/mol |
|---|---|
| Formula | C27H44N7O20P3S |
| Hydrogen Acceptors | 21 |
| Hydrogen Donors | 11 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 23 |
HMG-CoA (1553-55-5)
Score:
#1804 in Biochemistry
,
#3937 in Biology
,
#4955 in Chemistry
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- Upregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors (Circulation, 1998)
- The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals (Nature Medicine, 2000)
- HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway (Journal of Clinical Investigation, 2001)
- The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease (Nature, 2002)
- Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase (Proceedings of the National Academy of Sciences of the United States of America, 1998)
- Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. (Journal of Lipid Research, 1980)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C2N=CN=C3N)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)CC(C)(CC(=O)O)O)O
-
InChIKeyCABVTRNMFUVUDM-UHFFFAOYSA-N
- Pubchem - HMG-CoA
- Wikipedia - 3-hydroxy-3-methylglutaryl-CoA
-Hydroxy -methylglutaryl-CoA (HMG-CoA), also known as 3-hydroxy-3-methylglutaryl-CoA, is an intermediate in the mevalonate and ketogenesis pathways. It is formed from acetyl CoA and acetoacetyl CoA by HMG-CoA synthase. The research of Minor J.
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