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Dihydroergotamine mesylate

Weight	679.796 g/mol
Formula	C₃₄H₄₁N₅O₈S
Hydrogen Acceptors	8
Hydrogen Donors	4
Aromatic Rings	3
Rotatable Bonds	4

Dihydroergotamine mesylate (6190-39-2)

Agit · Dihydroergotamine · Migranal

Score: #136 in Neurology , #619 in Neuroscience , #2771 in Biology , #3477 in Chemistry

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Most-cited Publications

Dihydroergotamine and sumatriptan attenuate levels of CGRP in plasma in rat superior sagittal sinus during electrical stimulation of the trigeminal ganglion (Neuropharmacology, 1991)
Repetitive intravenous dihydroergotamine as therapy for intractable migraine (Neurology, 1986)
Central activation of the trigeminovascular pathway in the cat is inhibited by dihydroergotamine. A c-Fos and electrophysiological study. (Brain, 1996)
A Double-blind Study of Subcutaneous Dihydroergotamine vs Subcutaneous Sumatriptan in the Treatment of Acute Migraine (JAMA Neurology, 1996)
Comparative Effects of Dihydroergotamine and Noradrenaline on Resistance, Exchange and Capacitance Functions in the Peripheral Circulation (Clinical Science, 1970)
Ergotamine and Dihydroergotamine: History, Pharmacology, and Efficacy (Headache, 2003)

Areas of Application

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Alternate Names

Agit
Dihydroergotamine
Migranal
D.H.E. 45
DHE 45
DHE45
Dihydroergotamine Methanesulfonate
DET MS
Sanol Brand of Dihydroergotamine Mesylate
Fujisawa Brand of Dihydroergotamine Mesylate
Hormosan Brand of Dihydroergotamine Mesylate
Shire Brand of Dihydroergotamine Mesylate
Dihydroergotamin AL
D-Tamin retard L.U.T.
ergotam von ct
Dihytamin
Xcel Brand 1 of Dihydroergotamine Mesylate
Dihydergot
Seglor
ratiopharm Brand of Dihydroergotamine Mesylate
Pharmafrid Brand of Dihydroergotamine Mesylate
Ikaran
Angionorm
Anto Brand of Dihydroergotamine Mesylate
Dihydroergotamine-Sandoz
ct-Arzneimittel Brand of Dihydroergotamine Mesylate
DHE Puren
Tamik
Dihydroergotamine Sandoz
Novartis Brand of Dihydroergotamine Mesylate
Farmasan Brand of Dihydroergotamine Mesylate
Clavigrenin
Wernigeroide Brand of Dihydroergotamine Mesylate
DHE-ratiopharm
Ergomimet
Desitin Brand of Dihydroergotamine Mesylate
DHE ratiopharm
Verladyn
D Tamin retard L.U.T.
IPRAD Brand of Dihydroergotamine Mesylate
Orstanorm
Ergont
ct Arzneimittel Brand of Dihydroergotamine Mesylate
Verla Brand of Dihydroergotamine Mesylate
Q Pharm Brand of Dihydroergotamine Mesylate
Aliud Brand of Dihydroergotamine Mesylate
DHE-45
Alpharma Brand of Dihydroergotamine Mesylate
Xcel Brand 2 of Dihydroergotamine Mesylate
Erganton
Q-Pharm Brand of Dihydroergotamine Mesylate
Schwarz Brand of Dihydroergotamine Mesylate
DHE-Puren
Pierre Fabre Brand of Dihydroergotamine Mesylate
SMILES

CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C.CS(=O)(=O)O
InChIKey

ADYPXRFPBQGGAH-UHFFFAOYSA-N

External Links

Pubchem - Dihydroergotamine mesylate
Wikipedia - dihydroergotamine mesylate
Dihydroergotamine (DHE) is an ergot alkaloid used to treat migraines. It is a derivative of ergotamine. It is administered as a nasal spray or injection and has an efficacy similar to that of sumatriptan.