| Weight | 555.632 g/mol |
|---|---|
| Formula | C28H37N5O7 |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 7 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 15 |
Leu-enkephalin
Leucine Enkephalin · Leu Enkephalin · 5-Leucine Enkephalin
14-18-6, 58822-25-6, 59141-40-1
Score:
#738 in Neuroscience
,
#1343 in Biochemistry
,
#3265 in Biology
,
#4077 in Chemistry
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- Immunohistochemical studies using antibodies to leucine-enkephalin: Initial observations on the nervous system of the rat (Neuroscience, 1976)
- Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA. (Nature, 1982)
- Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli (Proceedings of the National Academy of Sciences of the United States of America, 1983)
- Regional distribution of leu and met enkephalin in rat brain (Neuropharmacology, 1977)
- The distribution of methionine-enkephalin and leucine-enkephalin in the brain and peripheral tissues (British Journal of Pharmacology, 1997)
- Evidence for a long Leu-enkephalin striopallidal pathway in rat brain (Nature, 1978)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Leucine Enkephalin
- Leu Enkephalin
- 5-Leucine Enkephalin
- Leu(5)-Enkephalin
- 5 Leucine Enkephalin
-
SMILESCC(C)CC(C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)C(CC2=CC=C(C=C2)O)N
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InChIKeyURLZCHNOLZSCCA-UHFFFAOYSA-N
- Pubchem - Leu-enkephalin
- Wikipedia - leucine enkephalin
Leu-enkephalin is an endogenous opioid peptide neurotransmitter with the amino acid sequence Tyr-Gly-Gly-Phe-Leu that is found naturally in the brains of many animals, including humans. It is one of the two forms of enkephalin; the other is met-enkephalin. The tyrosine residue at position 1 is thought to be analogous to the 3-hydroxyl group on morphine.
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Synthesis
benzene
+
Reactant
(Friedel-Crafts alkylation)
Reactant
+
Phenylalanylleucine
(Schotten-Baumann amide from acid)
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