| Weight | 362.499 g/mol |
|---|---|
| Formula | C18H26N4O2S |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 3 |
Mesulergine (64795-35-3)
Score:
#245 in Neurology
,
#1213 in Neuroscience
,
#5204 in Biology
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- Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: Radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, ()[125I]iodocyanopindolol, [3H]mesulergine and [3H]Ketanserin (European Journal of Pharmacology, 1985)
- Mesulergine, a selective serotonin-2 ligand in the rat cortex, does not label these receptors in porcine and human cortex: evidence for species differences in brain serotonin-2 receptors (European Journal of Pharmacology, 1984)
- A single point mutation (Phe340-->Leu340) of a conserved phenylalanine abolishes 4-[125I]iodo-(2,5-dimethoxy)phenylisopropylamine and [3H]mesulergine but not [3H]ketanserin binding to 5-hydroxytryptamine2 receptors. (Molecular Pharmacology, 1993)
- Regional distribution and cellular localization of 5-HT2C receptor mRNA in monkey brain: Comparison with [3H]mesulergine binding sites and choline acetyltransferase mRNA (Synapse, 2001)
- Autoradiographic distribution of 5HT7 receptors in the human brain using [3H]mesulergine: comparison to other mammalian species (British Journal of Pharmacology, 2004)
- [3H]Mesulergine, a selective ligand for serotonin-2 receptors (Life Sciences, 1983)
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Predict GHS Hazards for Any Chemical in silico.
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SMILESCN1CC(CC2C1CC3=CN(C4=CC=CC2=C34)C)NS(=O)(=O)N(C)C
-
InChIKeyJLVHTNZNKOSCNB-UHFFFAOYSA-N
- Pubchem - Mesulergine
- Wikipedia - mesulergine
Mesulergine is a psychoactive drug of the ergoline chemical class that acts on serotonin and dopamine receptors. The compound had entered clinical trials for the treatment of Parkinson's disease; however, further development was halted due to adverse histological abnormalities in rats.
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