| Weight | 318.501 g/mol |
|---|---|
| Formula | C21H34O2 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 0 |
| Rotatable Bonds | 1 |
Pregnanolone (128-20-1)
Score:
#812 in Neuroscience
,
#1541 in Biochemistry
,
#3566 in Biology
,
#4478 in Chemistry
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- Anxiolytic effects of the neuroactive steroid pregnanolone (3-OH-5-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum (Brain Research, 1999)
- Pregnanolone emulsion A preliminary pharmacokinetic and pharmacodynamic study of a new intravenous anaesthetic agent (Anaesthesia, 1990)
- Differential antagonism by epipregnanolone of alphaxalone and pregnanolone potentiation of [3H]flunitrazepam binding suggests more than one class of binding site for steroids at GABAA receptors (Neuropharmacology, 1993)
- Gamma-aminobutyric acidA receptor regulation: chronic treatment with pregnanolone uncouples allosteric interactions between steroid and benzodiazepine recognition sites. (Molecular Pharmacology, 1993)
- Enantioselectivity of Pregnanolone-Induced -Aminobutyric AcidA Receptor Modulation and Anesthesia (Journal of Pharmacology and Experimental Therapeutics, 2000)
- Photoaffinity labeling with a neuroactive steroid analogue: 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain (Journal of Biological Chemistry, 2003)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(=O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C
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InChIKeyAURFZBICLPNKBZ-UHFFFAOYSA-N
- Pubchem - Pregnanolone
- Wikipedia - eltanolone
Pregnanolone, also known as eltanolone (INN), as well as 3,5-tetrahydroprogesterone (3,5-THP) or 3-hydroxy-5-pregnan-20-one, is an endogenous neurosteroid that is biosynthesized from progesterone. It is a positive allosteric modulator of the GABAA receptor, as well as a negative allosteric modulator of the glycine receptor, and is known to have sedative, anxiolytic, anesthetic, and anticonvulsant effects. It was investigated for clinical use as a general anesthetic, but produced unwanted side effects such as convulsions on occasion, and for this reason was never marketed.
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