Weight | 313.397 g/mol |
---|---|
Formula | C19H23NO3 |
Hydrogen Acceptors | 4 |
Hydrogen Donors | 1 |
Aromatic Rings | 2 |
Rotatable Bonds | 6 |
Reboxetine
98769-81-4, 98819-76-2, 71620-89-8
Score:
#414 in Neuroscience
,
#1907 in Biology
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#2305 in Chemistry
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- The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression : results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine (Molecular Psychiatry, 2006)
- Reboxetine: a pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor (Biological Psychiatry, 2000)
- Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and selective serotonin reuptake inhibitor controlled trials. (BMJ, 2010)
- Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment (Psychopharmacology, 2005)
- Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim test (European Journal of Pharmacology, 2002)
- Reboxetine, a Selective Norepinephrine Reuptake Inhibitor, Is an Effective and Well-Tolerated Treatment for Panic Disorder (The Journal of Clinical Psychiatry, 2002)
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Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCOC1=CC=CC=C1OC(C2CNCCO2)C3=CC=CC=C3
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InChIKeyCBQGYUDMJHNJBX-UHFFFAOYSA-N
- Pubchem - Reboxetine
- Wikipedia - esreboxetine
Esreboxetine is a selective norepinephrine reuptake inhibitor which was under development by Pfizer for the treatment of neuropathic pain and fibromyalgia but failed to show significant benefit over currently available medications and was discontinued. It is the (S,S)-(+)-enantiomer of reboxetine and is even more selective in comparison. However, recently it has been shown that esreboxetine could be effective in fibromyalgia patients.
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SCHEMBL3973618
(Reductive amination)
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