| Weight | 452.595 g/mol |
|---|---|
| Formula | C27H36N2O4 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 10 |
Repaglinide (135062-02-1)
Score:
#760 in Biochemistry
,
#2566 in Chemistry
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- Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics. (Clinical Pharmacology & Therapeutics, 2005)
- Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes. (Diabetes, 1998)
- Effect of repaglinide addition to metformin monotherapy on glycemic control in patients with type 2 diabetes. (Diabetes Care, 1999)
- Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide (Diabetologia, 2003)
- Calcium silicate based microspheres of repaglinide for gastroretentive floating drug delivery: Preparation and in vitro characterization (Journal of Controlled Release, 2005)
- Cyclosporine markedly raises the plasma concentrations of repaglinide (Clinical Pharmacology & Therapeutics, 2005)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCOC1=C(C=CC(=C1)CC(=O)NC(CC(C)C)C2=CC=CC=C2N3CCCCC3)C(=O)O
-
InChIKeyFAEKWTJYAYMJKF-UHFFFAOYSA-N
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Synthesis
Reactant
+
147769-93-5
(Schotten-Baumann amide from acid)
2-Ethoxybenzoic acid
+
Reactant
(Friedel-Crafts alkylation)
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Repaglinide
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