| Weight | 241.251 g/mol |
|---|---|
| Formula | C9H15N5O3 |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 6 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 2 |
tetrahydrobiopterin (17528-72-2)
BPH4 · THBP · 5,6,7,8-tetrahydrobiopterin
Score:
#453 in Neuroscience
,
#759 in Biochemistry
,
#2089 in Biology
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#2563 in Chemistry
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- Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension (Journal of Clinical Investigation, 2003)
- Endothelial Regulation of Vasomotion in ApoE-Deficient Mice Implications for Interactions Between Peroxynitrite and Tetrahydrobiopterin (Circulation, 2001)
- Tetrahydrobiopterin biosynthesis, regeneration and functions (Biochemical Journal, 2000)
- Superoxide Generation from Endothelial Nitric-oxide Synthase A Ca2+/CALMODULIN-DEPENDENT AND TETRAHYDROBIOPTERIN REGULATORY PROCESS (Journal of Biological Chemistry, 1998)
- Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. (Journal of Clinical Investigation, 1997)
- Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols IMPLICATIONS FOR UNCOUPLING ENDOTHELIAL NITRIC-OXIDE SYNTHASE (Journal of Biological Chemistry, 2003)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - BPH4
- THBP
- 5,6,7,8-tetrahydrobiopterin
- tetrahydro-6-biopterin
- 5,6,7,8-tetrahydrodictyopterin
- 1-butanone, 1-(2,4,5-trihydroxyphenyl)
- phenylalanine hydroxylase cofactor
- 5,6,7,8-tetrahydrobiopterin, (S-(R*,S*))-isomer
- sapropterin dihydrochloride
- 5,6,7,8-erythro-tetrahydrobiopterin
- 2,4,5-trihydroxybutyrophenone
- 5,6,7,8-tetrahydro-L-erythrobiopterin
- 6R-L-erythro-5,6,7,8-tetrahydrobiopterin
- kuvan
- 6R-BH4
- D-threo-tetrahydrobiopterin
- sapropterin
- trihydroxybutyrophenone
- 2',4',5'-trihydroxybutyrophenone
-
SMILESCC(C(C1CNC2=C(N1)C(=O)N=C(N2)N)O)O
-
InChIKeyFNKQXYHWGSIFBK-UHFFFAOYSA-N
- Pubchem - tetrahydrobiopterin
- Wikipedia - Sapropterin
Tetrahydrobiopterin (BH4, THB), also known as sapropterin, is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and is a cofactor for the production of nitric oxide (NO) by the nitric oxide synthases. Chemically, its structure is that of a reduced pteridine derivative.
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