| Weight | 356.227 g/mol |
|---|---|
| Formula | C12H15Cl2NO5S |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 6 |
thiamphenicol (15318-45-3, 847-25-6)
Thiophenicol · Dextrosulfenidol · Thiomycetin
Score:
#428 in Microbiology
,
#1447 in Biochemistry
,
#3426 in Biology
,
#4278 in Chemistry
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- Sigma-Aldrich - thiamphenicol49.70 - 316.50 USD
- Fisher Scientific - Search for thiamphenicol
- TCI - thiamphenicol58.00 - 173.00 USD
- Dispersive liquidliquid microextraction followed by high-performance liquid chromatography as an efficient and sensitive technique for simultaneous determination of chloramphenicol and thiamphenicol in honey (Analytica Chimica Acta, 2009)
- A comparative study on the inhibitory actions of chloramphenicol, thiamphenicol and some fluorinated derivatives (Journal of Antimicrobial Chemotherapy, 1990)
- In vitro antibacterial activity of fluorinated analogs of chloramphenicol and thiamphenicol. (Antimicrobial Agents and Chemotherapy, 1981)
- Simultaneous determination and confirmation of chloramphenicol, thiamphenicol, florfenicol and florfenicol amine in chicken muscle by liquid chromatography-tandem mass spectrometry (Journal of Chromatography B, 2008)
- In vitro and in vivo antibacterial activities of florfenicol, a new fluorinated analog of thiamphenicol, against fish pathogens. (Fish Pathology, 1987)
- Simultaneous determination of residues of chloramphenicol, florfenicol, florfenicol amine, and thiamphenicol in shrimp tissue by gas chromatography with electron capture detection. (Journal of AOAC International, 2000)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Thiophenicol
- Dextrosulfenidol
- Thiomycetin
- Vicemycetin
- Thiamcol
- Raceophenidol
- Urfamycin
-
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-
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- Pubchem - thiamphenicol
- Wikipedia - Thiamphenicol
Thiamphenicol (also known as thiophenicol and dextrosulphenidol) is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, it is insoluble in water, but highly soluble in lipids.
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Synthesis
Reactant
+
4-Chlorophenyl methyl sulfone
(Grignard alcohol)
METHYL PHENYL SULFONE
+
Reactant
(Friedel-Crafts alkylation)
2,2-Dichloroacetamide
+
Reactant
(Alkylation of primary amines)
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thiamphenicol
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