| Weight | 489.406 g/mol |
|---|---|
| Formula | C27H22Cl2N4O |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 5 |
| Rotatable Bonds | 4 |
Tipifarnib (192185-68-5, 192185-72-1)
"What do you need help with?"
LabBot
- Sigma-Aldrich - Tipifarnib99.00 - 399.00 USD
- Fisher Scientific - Search for Tipifarnib
- TCI - Search for Tipifarnib
- Phase III Trial of Gemcitabine Plus Tipifarnib Compared With Gemcitabine Plus Placebo in Advanced Pancreatic Cancer (Journal of Clinical Oncology, 2004)
- Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma (Blood, 2004)
- A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia (Blood, 2007)
- Phase II trial of tipifarnib in patients with recurrent malignant glioma either receiving or not receiving enzyme-inducing antiepileptic drugs : a North American Brain Tumor Consortium Study (Journal of Clinical Oncology, 2006)
- Phase I Trial and Pharmacokinetic Study of the Farnesyltransferase Inhibitor Tipifarnib in Children With Refractory Solid Tumors or Neurofibromatosis Type I and Plexiform Neurofibromas (Journal of Clinical Oncology, 2006)
- A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older (Blood, 2009)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCN1C=NC=C1C(C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N
-
InChIKeyPLHJCIYEEKOWNM-UHFFFAOYSA-N
- Pubchem - Tipifarnib
- Wikipedia - Tipifarnib
Tipifarnib (INN, proposed trade name Zarnestra) is a farnesyltransferase inhibitor that is being investigated in patients 65 years of age and older with newly diagnosed acute myeloid leukemia (AML). It inhibits the Ras kinase in a post-translational modification step before the kinase pathway becomes hyperactive. It inhibits prenylation of the CaaX tail motif, which allows Ras to bind to the membrane where it is active.
Suppliers
Most-cited Publications
Safety
Alternate Names
External Links
Similar Compounds
Darifenacin hydrobromide
(133099-07-7)
1 alternate name
3 suppliers
Bromadiolone
(28772-56-7)
1 alternate name
3 suppliers
93-46-9
(93-46-9)
1 alternate name
3 suppliers
LOFEPRAMINE
(23047-25-8)
1 alternate name
3 suppliers
Bepotastine besilate
(190786-44-8)
1 alternate name
3 suppliers
Solvent green 3
(128-80-3)
1 alternate name
3 suppliers
Quinacridone
(1047-16-1)
1 alternate name
3 suppliers
Bazedoxifene acetate
(198481-33-3)
1 alternate name
3 suppliers
Crystal violet lactone
(1552-42-7)
1 alternate name
3 suppliers
CHLOROPHACINONE
(3691-35-8)
1 alternate name
6 safety hazards
3 suppliers
ATOVAQUONE
(94015-53-9, 95233-18-4)
1 alternate name
3 suppliers
Trifenmorph
(1420-06-0)
1 alternate name
2 safety hazards
3 suppliers
Basic violet 14
(58969-01-0, 632-99-5)
1 alternate name
1 safety hazard
3 suppliers
RALOXIFENE HYDROCHLORIDE
(82640-04-8)
1 alternate name
3 suppliers
Vat yellow 4
(128-66-5)
1 alternate name
3 suppliers
Conivaptan hydrochloride
(168626-94-6)
1 alternate name
3 suppliers
LEVOCABASTINE HYDROCHLORIDE
(79547-78-7)
1 alternate name
3 suppliers
Pibenzimol
(23491-44-3, 23491-45-4)
1 alternate name
3 suppliers
AZELASTINE HYDROCHLORIDE
(79307-93-0, 37932-96-0)
1 alternate name
3 suppliers
Meclizine hydrochloride
(410538-37-3, 36236-67-6, 31884-77-2)
1 alternate name
3 suppliers
Fuchsine Base
(3248-93-9)
1 alternate name
3 suppliers
Disperse Red 60
(17418-58-5, 70956-30-8, 12223-37-9)
1 alternate name
3 suppliers
3-Quinuclidinyl benzilate
(6581-06-2)
1 alternate name
3 suppliers
(R)-(-)-3-Quinuclidinyl benzilate
(62869-69-6)
1 alternate name
3 suppliers
Leucomalachite green
(129-73-7)
1 alternate name
1 safety hazard
3 suppliers
CYTOCHALASIN B
(14930-96-2)
1 alternate name
3 suppliers
Tris(4-isopropylphenyl) phosphate
(2502-15-0, 68937-41-7, 26967-76-0)
1 alternate name
3 suppliers
CYTOCHALASIN B
(14930-96-2)
1 alternate name
3 suppliers
14930-96-2
(14930-96-2)
1 alternate name
3 suppliers
CYTOCHALASIN B
(14930-96-2)
1 alternate name
3 suppliers
CYTOCHALASIN B
(14930-96-2)
1 alternate name
3 suppliers
CYTOCHALASIN B
(14930-96-2)
1 alternate name
3 suppliers
ONO-RS 411
(103177-37-3)
1 alternate name
3 suppliers
Tris(3,4-dimethylphenyl) phosphate
(3862-11-1)
1 alternate name
3 suppliers
Difenoconazole
(119446-68-3)
1 alternate name
3 safety hazards
3 suppliers
Trimipramine maleate
(138283-60-0, 138283-61-1, 521-78-8)
1 alternate name
3 suppliers
(-)-Epicatechin gallate
(1257-08-5)
1 alternate name
3 suppliers
Diphacinone
(82271-36-1, 82-66-6)
1 alternate name
4 safety hazards
3 suppliers
Olmesartan
(144689-63-4, 144689-24-7)
1 alternate name
3 suppliers
Methoxyfenozide
(161050-58-4)
1 alternate name
3 suppliers
Dabigatran
(211914-51-1)
1 alternate name
3 suppliers
Dibenz[a,j]acridine
(224-42-0)
1 alternate name
1 safety hazard
3 suppliers
Paroxetine hydrochloride
(78246-49-8, 110429-35-1)
1 alternate name
3 suppliers
Escitalopram oxalate
(219861-08-2)
1 alternate name
3 suppliers
Tipifarnib
CAS Directory
