| Weight | 302.414 g/mol |
|---|---|
| Formula | C19H26O3 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 1 |
2-Methoxyestradiol (362-07-2)
Score:
#1010 in Biochemistry
,
#2648 in Biology
,
#3307 in Chemistry
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- Inhibition of Angiogenesis and Breast Cancer in Mice by the Microtubule Inhibitors 2-Methoxyestradiol and Taxol (Cancer Research, 1997)
- 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site. (Proceedings of the National Academy of Sciences of the United States of America, 1994)
- The Antiangiogenic Property of Docetaxel Is Synergistic with a Recombinant Humanized Monoclonal Antibody against Vascular Endothelial Growth Factor or 2-Methoxyestradiol but Antagonized by Endothelial Growth Factors (Cancer Research, 2001)
- Is 2-Methoxyestradiol an Endogenous Estrogen Metabolite That Inhibits Mammary Carcinogenesis? (Cancer Research, 1998)
- 2-Methoxyestradiol: an endogenous antiangiogenic and antiproliferative drug candidate. (Cancer and Metastasis Reviews, 2000)
- Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site. (Journal of Medicinal Chemistry, 1995)
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SMILESCC12CCC3C(C1CCC2O)CCC4=CC(=C(C=C34)OC)O
-
InChIKeyCQOQDQWUFQDJMK-UHFFFAOYSA-N
- Pubchem - 2-Methoxyestradiol
- Wikipedia - 2-methoxyestradiol
2-Methoxyestradiol (2-ME2) is a natural metabolite of estradiol. As an experimental drug candidate, it is being developed under the tradename of Panzem. It prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis), hence it is an angiogenesis inhibitor.
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