5-azacytidine (320-67-2)

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Suppliers

• Sigma-Aldrich - 5-azacytidine
  20.50 - 296.50 USD
• Fisher Scientific - Search for 5-azacytidine
• TCI - Search for 5-azacytidine

Most-cited Publications

• Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study (Lancet Oncology, 2009)
• Randomized Controlled Trial of Azacitidine in Patients With the Myelodysplastic Syndrome: A Study of the Cancer and Leukemia Group B (Journal of Clinical Oncology, 2002)
• Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. (Muscle & Nerve, 1995)
• Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine. (Cell, 1979)
• 5-Azacytidine and 5-aza-2-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy (Oncogene, 2002)
• Azacitidine Prolongs Overall Survival Compared With Conventional Care Regimens in Elderly Patients With Low Bone Marrow Blast Count Acute Myeloid Leukemia (Journal of Clinical Oncology, 2010)

Areas of Application

Safety

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  Predict GHS Hazards for Any Chemical in silico.
  Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more.
• H302: Harmful if swallowed
  Warning Acute toxicity, oral - Category 4
• H350: May cause cancer
  Danger Carcinogenicity - Category 1A, 1B
• H372: Causes damage to organs through prolonged or repeated exposure
  Danger Specific target organ toxicity, repeated exposure - Category 1

Trends

Alternate Names

• Azacytidine
• Azacitidine
• Vidaza
• 5 Azacytidine
• NSC-102816
• NSC102816
• NSC 102816
• Pharmion Brand of Azacitidine
• SMILES
  C1=NC(=NC(=O)N1C2C(C(C(O2)CO)O)O)N
• InChIKey
  NMUSYJAQQFHJEW-UHFFFAOYSA-N

External Links

• Pubchem - 5-azacytidine
• Wikipedia - azacitidine
  Azacitidine (INN; trade name Vidaza) is a chemical analog of cytidine, a nucleoside in DNA and RNA. Azacitidine and its deoxy derivative, decitabine (also known as 5-aza-2-deoxycytidine), are used in the treatment of myelodysplastic syndrome. Both drugs were first synthesized in Czechoslovakia as potential chemotherapeutic agents for cancer.

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5-azacytidine

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