| Weight | 420.465 g/mol |
|---|---|
| Formula | C24H24N2O5 |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 8 |
Amtolmetin guacil (87344-06-7)
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- Alkenyl C-H insertion of iodonium ylides into pyrroles: studies toward the total syntheses of tolmetin and amtolmetin guacil. (Organic Letters, 2003)
- A Meta-Analysis of the Tolerability of Amtolmetin Guacil, a Novel, Effective Nonsteroidal Anti-Inflammatory Drug, Compared with Established Agents (Clinical Drug Investigation, 1999)
- Use of Amtolmetin Guacil as an anti-inflammatory agent, which also inhibits gastric secretion (1996)
- Validation and clinical application of an LCESIMS/MS method for simultaneous determination of tolmetin and MED5, the metabolites of amtolmetin guacil in human plasma (Biomedical Chromatography, 2010)
- Species difference in the in vitro and in vivo metabolism of amtolmetin guacil. (Drug Research, 2011)
- Application of a stability-indicating HPTLC method for quantitative analysis of amtolmetin guacil in a pharmaceutical dosage form (Acta Chromatographica, 2009)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC1=CC=C(C=C1)C(=O)C2=CC=C(N2C)CC(=O)NCC(=O)OC3=CC=CC=C3OC
-
InChIKeyCWJNMKKMGIAGDK-UHFFFAOYSA-N
- Pubchem - Amtolmetin guacil
- Wikipedia - amtolmetin guacil
Amtolmetin guacil is a NSAID which is a prodrug of tolmetin sodium.
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Most-cited Publications
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Alternate Names
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Synthesis
Methanone, (4-methylphenyl)(1-methyl-1H-pyrrol-2-yl)-
+
Reactant
(Friedel-Crafts alkylation)
Reactant
+
4-Chlorotoluene
(Grignard carbonyl)
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Amtolmetin guacil
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