| Weight | 588.666 g/mol |
|---|---|
| Formula | C27H40N8O7 |
| Hydrogen Acceptors | 7 |
| Hydrogen Donors | 7 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 9 |
Cilengitide (188968-51-6)
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- Randomized Phase II Study of Cilengitide, an Integrin-Targeting Arginine-Glycine-Aspartic Acid Peptide, in Recurrent Glioblastoma Multiforme (Journal of Clinical Oncology, 2008)
- Phase I/IIa Study of Cilengitide and Temozolomide With Concomitant Radiotherapy Followed by Cilengitide and Temozolomide Maintenance Therapy in Patients With Newly Diagnosed Glioblastoma (Journal of Clinical Oncology, 2010)
- Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation (Anti-cancer Agents in Medicinal Chemistry, 2010)
- Phase I and Correlative Biology Study of Cilengitide in Patients With Recurrent Malignant Glioma (Journal of Clinical Oncology, 2007)
- Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial (Lancet Oncology, 2014)
- Phase I and pharmacokinetic study of continuous twice weekly intravenous administration of Cilengitide (EMD 121974), a novel inhibitor of the integrins v3 and v5 in patients with advanced solid tumours (European Journal of Cancer, 2003)
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- Pubchem - Cilengitide
- Wikipedia - cilengitide
Cilengitide (EMD 121974) is a molecule designed and synthesized at the Technical University Munich in collaboration with Merck KGaA in Darmstadt. It is based on the cyclic peptide cyclo(-RGDfV-), which is selective for v integrins, which are important in angiogenesis (forming new blood vessels), and other aspects of tumor biology. Hence, it is under investigation for the treatment of glioblastoma, where it may act by inhibiting angiogenesis, and influencing tumor invasion and proliferation.
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