| Weight | 368.524 g/mol |
|---|---|
| Formula | C26H28N2 |
| Hydrogen Acceptors | 2 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 6 |
cinnarizine (298-57-7, 16699-20-0)
Cinna · Stugeron · R 516
Score:
#91 in Neurology
,
#454 in Neuroscience
,
#2099 in Biology
,
#2577 in Chemistry
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- cyclodextrin derivatives, SBE4CD and HPCD, increase the oral bioavailability of cinnarizine in beagle dogs (Journal of Pharmaceutical Sciences, 1995)
- Flunarizine- and cinnarizine-induced extrapyramidal reactions. (Neurology, 1987)
- A comparison of the inhibitory effect of cinnarizine and papaverine on the noradrenaline- and calcium-evoked contraction of isolated rabbit aorta and mesenteric arteries. (European Journal of Pharmacology, 1979)
- In Vitro Gastrointestinal Lipolysis of Four Formulations of Piroxicam and Cinnarizine with the Self Emulsifying Excipients Labrasol and Gelucire 44/14 (Pharmaceutical Research, 2009)
- ANTICONVULSIVE PROPERTIES OF CINNARIZINE AND FLUNARIZINE IN RATS AND MICE (Drug Research, 1975)
- Movement disorders and depression due to flunarizine and cinnarizine (Movement Disorders, 1989)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Cinna
- Stugeron
- R 516
- Cinarizine
- cinnarizin von ct
- Cinnarizin Siegfried
- Dihydrochloride Cinnarizine
- R516
- Aliud Brand of Cinnarizine
- R-516
- Cinnarizine, (E)-Isomer
- 1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine
- Kendrick Brand of Cinnarizine
- Cinnarizine L-Tartrate (1:1)
- Cinnarizin-ratiopharm
- Cinarizina Ratiopharm
- Cinazire
- Cinnipirine
- Janssen Brand of Cinnarizine
- Cisaken
- Dimitronal
- Cinnarizine L-Tartrate
- Alpharma Brand of Cinnarizine
- Inkeysa Brand of Cinnarizine
- ratiopharm Brand of Cinnarizine
- Cinnarizine L Tartrate
- Ashbourne Brand of Cinnarizine
- Cinarizina Inkey
- Artu Brand of Cinnarizine
- Esteve Brand of Cinnarizine
- Stugeron Forte
- ct-Arzneimittel Brand of Cinnarizine
- Cinnarizin AL
-
SMILESC1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4
-
InChIKeyDERZBLKQOCDDDZ-UHFFFAOYSA-N
- Pubchem - cinnarizine
- Wikipedia - cinnarizine
Cinnarizine is an antihistamine and calcium channel blocker of the diphenylmethylpiperazine group. It is also known to promote cerebral blood flow, and so is used to treat cerebral apoplexy, post-trauma cerebral symptoms, and cerebral arteriosclerosis. However, it is more commonly prescribed for nausea and vomiting due to motion sickness or other sources such as chemotherapy, vertigo, or Mnire's disease.
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Synthesis
benzene
+
Reactant
(Friedel-Crafts alkylation)
Reactant
+
1-Benzhydrylpiperazine
(Chan-Lam coupling reaction)
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cinnarizine
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