| Weight | 399.443 g/mol |
|---|---|
| Formula | C22H25NO6 |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 5 |
colchicine (64-86-8)
Colchicine, (+-)-Isomer · Colchicine, (R)-Isomer
Score:
#31 in Biochemistry
,
#35 in Neuroscience
,
#186 in Biology
,
#194 in Chemistry
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- Colchicine-binding protein of mammalian brain and its relation to microtubules (Biochemistry, 1968)
- Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain. (Nature, 2004)
- THE MECHANISM OF ACTION OF COLCHICINE Binding of Colchincine-3H to Cellular Protein (Journal of Cell Biology, 1967)
- Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine (Proceedings of the National Academy of Sciences of the United States of America, 1987)
- Immunocytochemical localization of glutamic acid decarboxylase in neuronal somata following colchicine inhibition of axonal transport. (Brain Research, 1978)
- A colchicine, hypotonic citrate, squash sequence for mammalian chromosomes. (Biotechnic & Histochemistry, 1956)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - H300: Fatal if swallowed
Danger Acute toxicity, oral - Category 1, 2 - Colchicine, (+-)-Isomer
- Colchicine, (R)-Isomer
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SMILESCC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
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InChIKeyIAKHMKGGTNLKSZ-UHFFFAOYSA-N
- Pubchem - colchicine
- Wikipedia - Colchicine
Colchicine is a medication most commonly used to treat gout. It is a toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum (autumn crocus, Colchicum autumnale, also known as "meadow saffron"). Adverse effects are primarily gastrointestinal upset at high doses.
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