| Weight | 461.386 g/mol |
|---|---|
| Formula | C21H30Cl2N2O5 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 2 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 14 |
Dexloxiglumide (119817-90-2)
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- Effect of CCK-1 Antagonist, Dexloxiglumide, in Female Patients with Irritable Bowel Syndrome: A Pharmacodynamic and Pharmacogenomic Study (The American Journal of Gastroenterology, 2005)
- Effect of dexloxiglumide and spiroglumide, two new CCK-receptor antagonists, on gastric emptying and secretion in the rat: evaluation of their receptor selectivity in vivo. (Alimentary Pharmacology & Therapeutics, 1996)
- Dexloxiglumide Rotta Research Lab. (Current opinion in investigational drugs, 2002)
- Pharmacokinetics of dexloxiglumide after administration of single and repeat oral escalating doses in healthy young males (Principles and Practice of Constraint Programming, 2002)
- The CCK1 receptor antagonist dexloxiglumide is effective and safe in female patients with constipation predominant irritable bowel syndrome (The American Journal of Gastroenterology, 2001)
- Pharmacokinetics and metabolism of the cholecystokinin antagonist dexloxiglumide in male human subjects (Xenobiotica, 2003)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCCCCCN(CCCOC)C(=O)C(CCC(=O)O)NC(=O)C1=CC(=C(C=C1)Cl)Cl
-
InChIKeyQNQZBKQEIFTHFZ-UHFFFAOYSA-N
- Pubchem - Dexloxiglumide
- Wikipedia - dexloxiglumide
Dexloxiglumide is a drug which acts as a cholecystokinin antagonist, selective for the CCKA subtype. It inhibits gastrointestinal motility and reduces gastric secretions, and despite older selective CCKA antagonists such as lorglumide and devazepide having had only limited success in trials and ultimately never making it into clinical use, dexloxiglumide is being investigated as a potential treatment for a variety of gastrointestinal problems including irritable bowel syndrome, dyspepsia, constipation and pancreatitis, and has had moderate success so far although trials are still ongoing.
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Synthesis
n-Pentylboronic acid
+
Reactant
(Chan-Lam coupling reaction)
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