| Weight | 452.598 g/mol |
|---|---|
| Formula | C30H32N2O2 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 8 |
DIPHENOXYLATE (3810-80-8, 915-30-0)
Diphenoxylate Hydrochloride · Diphenoxylate Monohydrochloride
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- Double-blind cross-over study comparing loperamide codeine and diphenoxylate in the treatment of chronic diarrhea (Gastroenterology, 1980)
- Effects of E prostaglandins, diphenoxylate and morphine on intestinal motility in vivo (European Journal of Pharmacology, 1975)
- Unfavorable effect of atropine-diphenoxylate (Lomotil) therapy in lincomycin-caused diarrhea. (JAMA, 1976)
- Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 1: in vivo oral pharmacology and acute toxicity. Comparison with morphine, codeine, diphenoxylate and difenoxine. (Drug Research, 1974)
- Acute effect of diphenoxylate with atropine (Lomotil) in patients with chronic diarrhea and fecal incontinence (Gastroenterology, 1980)
- A DOUBLE BLIND CROSSOVER COMPARISON OF LOPERAMIDE WITH DIPHENOXYLATE IN THE SYMPTOMATIC TREATMENT OF CHRONIC DIARRHEA (Gastroenterology, 1976)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Diphenoxylate Hydrochloride
- Diphenoxylate Monohydrochloride
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SMILESCCOC(=O)C1(CCN(CC1)CCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4
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InChIKeyHYPPXZBJBPSRLK-UHFFFAOYSA-N
- Pubchem - DIPHENOXYLATE
- Wikipedia - diphenoxylate
Diphenoxylate (INN, BAN) (brand name Diocalm), or diphenoxylate hydrochloride (USAN), is a centrally active opioid drug of the phenylpiperidine series that is used for the treatment of diarrhea. It acts by slowing intestinal contractions and peristalsis allowing the body to consolidate intestinal contents and prolong transit time, thus allowing the intestines to draw moisture out of them at a normal or higher rate and therefore stop the formation of loose and liquid stools. It is the main active ingredient in the anti-peristaltic medication Lomotil, which also contains atropine.
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