| Weight | 788.684 g/mol |
|---|---|
| Formula | C42H50Cl4N2O4 |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 0 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 16 |
Estradiol mustard (22966-79-6)
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- Purification and distribution of a major protein in rat prostate that binds estramustine, a nitrogen mustard derivative of estradiol-17 beta (Proceedings of the National Academy of Sciences of the United States of America, 1979)
- Growth and cell survival following treatment with estramustine nor-nitrogen mustard, estradiol and testosterone of a human prostatic cancer cell line (DU 145). (The Journal of Urology, 1982)
- Binding characteristics of a major protein in rat ventral prostate cytosol that interacts with estramustine, a nitrogen mustard derivative of 17-estradiol (Cancer Research, 1979)
- Studies on the Antiprostatic Action of Estracyt, a Nitrogen Mustard of Estradiol (Cancer Research, 1974)
- Studies on Phenolic Steroids in Human Subjects. XIV. Fate of a Nitrogen Mustard of Estradiol-17 (The Journal of Clinical Endocrinology and Metabolism, 1975)
- Affinity of estradiol mustard for estrogen receptors and its enzymatic degradation in uterine and breast cancer cytosols (International Journal of Cancer, 1976)
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SMILESCC12CCC3C(C1CCC2OC(=O)CC4=CC=C(C=C4)N(CCCl)CCCl)CCC5=C3C=CC(=C5)OC(=O)CC6=CC=C(C=C6)N(CCCl)CCCl
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InChIKeyLRSFXIJGHRPOQQ-UHFFFAOYSA-N
- Pubchem - Estradiol mustard
- Wikipedia - estradiol mustard
Estradiol mustard (developmental code name NSC-112259), also known as chlorphenacyl estradiol diester, as well as estradiol 3,17-bis(4-(bis(2-chloroethyl)amino)phenyl)acetate, is a synthetic, steroidal estrogen and alkylating antineoplastic agent and a chlorphenacyl nitrogen mustard-coupled estrogen ester that was never marketed. It is selectively distributed into estrogen receptor (ER)-positive tissues such as ER-expressing tumors like those seen in breast and prostate cancers. For this reason, estradiol mustard and other cytostatic-linked estrogens like estramustine phosphate have reduced toxicity relative to non-linked nitrogen mustard alkylating antineoplastic agents.
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