| Weight | 303.141 g/mol |
|---|---|
| Formula | C13H12Cl2O4 |
| Hydrogen Acceptors | 3 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 6 |
ETHACRYNIC ACID (58-54-8)
Edecrin · Ethacrynate Sodium · Ethacrinic Acid
Score:
#384 in Biochemistry
,
#1341 in Biology
,
#1561 in Chemistry
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- Ethacrynic Acid and Piriprost as Enhancers of Cytotoxicity in Drug Resistant and Sensitive Cell Lines (Cancer Research, 1988)
- Effect of ethacrynic acid, furosemide, and ouabain upon the endolymphatic potential and upon high energy phosphates of the stria vascularis. (Laryngoscope, 1978)
- Interaction of Kanamycin and Ethacrynic Acid: Severe Cochlear Damage in Guinea Pigs (Archives of Otolaryngology-head & Neck Surgery, 1973)
- Effects of ethacrynic acid and cardiac glycosides upon a membrane adenosinetriphosphatase of renal cortex (Archives of Biochemistry and Biophysics, 1965)
- Redistribution of Renal Blood Flow Produced by Furosemide and Ethacrynic Acid (Circulation Research, 1967)
- RENOTROPIC CHARACTERISTICS OF ETHACRYNIC ACID: A PHENOXYACETIC SALURETIC-DIURETIC AGENT (Journal of Pharmacology and Experimental Therapeutics, 1965)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Edecrin
- Ethacrynate Sodium
- Ethacrinic Acid
- Etacrynic Acid
- Ethacrynic Acid, Sodium Salt
- Hydromedin
-
SMILESCCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl
-
InChIKeyAVOLMBLBETYQHX-UHFFFAOYSA-N
- Pubchem - ETHACRYNIC ACID
- Wikipedia - ethacrynic acid
Etacrynic acid (INN) or ethacrynic acid (USAN), trade name Edecrin, is a loop diuretic used to treat high blood pressure and the swelling caused by diseases like congestive heart failure, liver failure, and kidney failure. Unlike the other loop diuretics, etacrynic acid is not a sulfonamide and thus, its use is not contraindicated in those with sulfa allergies. Ethacrynic acid is a phenoxyacetic acid derivative containing a ketone group and a methylene group.
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Synthesis
Reactant
+
chloroacetic acid
(Williamson ether)
Reactant
+
dimethyl sulfide
(Corey-Kim oxidation of secondary alcohols)
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