| Weight | 1304.548 g/mol |
|---|---|
| Formula | C59H89N19O13S |
| Hydrogen Acceptors | 17 |
| Hydrogen Donors | 15 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 30 |
Icatibant (130308-48-4, 138614-30-9)
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- Icatibant, a New Bradykinin-Receptor Antagonist, in Hereditary Angioedema (The New England Journal of Medicine, 2010)
- Treatment Of Acute Edema Attacks In Hereditary Angioedema With A Bradykinin Receptor-2 Antagonist (Icatibant) (The Journal of Allergy and Clinical Immunology, 2007)
- Therapeutic Efficacy of Icatibant in Angioedema Induced by Angiotensin-Converting Enzyme Inhibitors: A Case Series (Annals of Emergency Medicine, 2010)
- Randomized placebo-controlled trial of the bradykinin B2 receptor antagonist icatibant for the treatment of acute attacks of hereditary angioedema: the FAST-3 trial (Annals of Allergy Asthma & Immunology, 2011)
- Efficacy and tolerability of Icatibant (Hoe 140) in patients with moderately severe chronic bronchial asthma (Immunopharmacology, 1996)
- Inhibition of bradykinin-induced vasodilation in human forearm vasculature by icatibant, a potent B2-receptor antagonist. (British Journal of Clinical Pharmacology, 1994)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC1CCC2C(C1)CC(N2C(=O)C3CC4=CC=CC=C4CN3C(=O)C(CO)NC(=O)C(CC5=CC=CS5)NC(=O)CNC(=O)C6CC(CN6C(=O)C7CCCN7C(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)N)O)C(=O)NC(CCCN=C(N)N)C(=O)O
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- Pubchem - Icatibant
- Wikipedia - icatibant
Icatibant, trade name Firazyr, is medication that has been approved by the European Commission for the symptomatic treatment of acute attacks of hereditary angioedema (HAE) in adults with C1-esterase-inhibitor deficiency. It is not effective in angioedema caused by medication from the ACE inhibitor class, as shown in a 2017 trial. It is a peptidomimetic consisting of ten amino acids, which is a selective and specific antagonist of bradykinin B2 receptors.
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