| Weight | 454.447 g/mol |
|---|---|
| Formula | C20H22N8O5 |
| Hydrogen Acceptors | 10 |
| Hydrogen Donors | 5 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 9 |
Methotrexate (59-05-2)
Amethopterin · Methotrexate Sodium · Mexate
Score:
#43 in Biochemistry
,
#233 in Biology
,
#243 in Chemistry
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- Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. (The New England Journal of Medicine, 2000)
- Infliximab (chimeric anti-tumour necrosis factor monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial (The Lancet, 1999)
- A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. (The New England Journal of Medicine, 1999)
- A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis. (The New England Journal of Medicine, 2000)
- Adalimumab, a fully human antitumor necrosis factor monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: The ARMADA trial (Arthritis & Rheumatism, 2003)
- Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis (Arthritis & Rheumatism, 1998)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Amethopterin
- Methotrexate Sodium
- Mexate
- Dicesium Salt Methotrexate
- Methotrexate, Disodium Salt
- Methotrexate, (DL)-Isomer
- Methotrexate, (D)-Isomer
- Methotrexate Hydrate
- Methotrexate, Sodium Salt
-
SMILESCN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
-
InChIKeyFBOZXECLQNJBKD-UHFFFAOYSA-N
- Pubchem - Methotrexate
- Wikipedia - methotrexate sodium
Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune system suppressant. It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and for medical abortions. Types of cancers it is used for include breast cancer, leukemia, lung cancer, lymphoma, and osteosarcoma.
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Alternate Names
Estimated Properties
| Boiling Point | 628.25 C | EPA T.E.S.T. |
|---|---|---|
| Density | 1.64 g/cm3 | EPA T.E.S.T. |
| Flash Point | 439.91 C | EPA T.E.S.T. |
| Water Solubility | 146 mg/L | EPA T.E.S.T. |
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Methotrexate
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