| Weight | 477.481 g/mol |
|---|---|
| Formula | C23H23N7O5 |
| Hydrogen Acceptors | 9 |
| Hydrogen Donors | 5 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 10 |
Pralatrexate (146464-95-1)
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- Pralatrexate in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma: Results From the Pivotal PROPEL Study (Journal of Clinical Oncology, 2011)
- Phase II-I-II Study of Two Different Doses and Schedules of Pralatrexate, a High-Affinity Substrate for the Reduced Folate Carrier, in Patients With Relapsed or Refractory Lymphoma Reveals Marked Activity in T-Cell Malignancies (Journal of Clinical Oncology, 2009)
- Pralatrexate, a novel class of antifol with high affinity for the reduced folate carrier-type 1, produces marked complete and durable remissions in a diversity of chemotherapy refractory cases of T-cell lymphoma (British Journal of Haematology, 2007)
- Identification of an active, well-tolerated dose of pralatrexate in patients with relapsed or refractory cutaneous T-cell lymphoma (Blood, 2012)
- The Schedule-Dependent Effects of the Novel Antifolate Pralatrexate and Gemcitabine Are Superior to Methotrexate and Cytarabine in Models of Human Non-Hodgkin's Lymphoma (Clinical Cancer Research, 2006)
- Pralatrexate is Synergistic with the Proteasome Inhibitor Bortezomib in In Vitro and In Vivo Models of T-Cell Lymphoid Malignancies (Clinical Cancer Research, 2010)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
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- Pubchem - Pralatrexate
- Wikipedia - pralatrexate
Pralatrexate (brand name Folotyn) is an anti-cancer therapy. It is the first drug approved as a treatment for patients with relapsed or refractory peripheral T-cell lymphoma, or PTCL a biologically diverse group of aggressive blood cancers that have a poor prognosis.
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2,4-Diaminopteridine
+
Reactant
(Friedel-Crafts alkylation)
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Pralatrexate
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