| Weight | 357.435 g/mol |
|---|---|
| Formula | C18H19N3O3S |
| Hydrogen Acceptors | 6 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 7 |
rosiglitazone (122320-73-4)
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#207 in Neuroscience
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#256 in Biochemistry
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#970 in Biology
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#1076 in Chemistry
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- Sigma-Aldrich - rosiglitazone69.80 - 283.00 USD
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- Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes (The New England Journal of Medicine, 2007)
- Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. (The New England Journal of Medicine, 2006)
- Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. (The Lancet, 2006)
- Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial (The Lancet, 2009)
- The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways (Journal of Biological Chemistry, 2002)
- Effect of Rosiglitazone Treatment on Nontraditional Markers of Cardiovascular Disease in Patients With Type 2 Diabetes Mellitus (Circulation, 2002)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3
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- Pubchem - rosiglitazone
- Wikipedia - rosiglitazone
Rosiglitazone (trade name Avandia) is an antidiabetic drug in the thiazolidinedione class. It works as an insulin sensitizer, by binding to the PPAR in fat cells and making the cells more responsive to insulin. It is marketed by the pharmaceutical company GlaxoSmithKline (GSK) as a stand-alone drug or for use in combination with metformin or with glimepiride.
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Synthesis
74772-78-4
+
Reactant
(Williamson ether)
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rosiglitazone
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