| Weight | 272.37 g/mol |
|---|---|
| Formula | C12H20N2O3S |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 6 |
sotalol (3930-20-9)
Score:
#9 in Medicinal chemistry
,
#9 in Physiology
,
#947 in Biochemistry
,
#2505 in Biology
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- Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction (The Lancet, 1996)
- Amiodarone versus Sotalol for Atrial Fibrillation (The New England Journal of Medicine, 2005)
- Comparison of -Blockers, Amiodarone Plus -Blockers, or Sotalol for Prevention of Shocks From Implantable Cardioverter Defibrillators: The OPTIC Study: A Randomized Trial (JAMA, 2006)
- CONTROLLED TRIAL OF SOTALOL FOR ONE YEAR AFTER MYOCARDIAL INFARCTION (The Lancet, 1982)
- Sex Difference in Risk of Torsade de Pointes With d,l-Sotalol (Circulation, 1996)
- Prevention of Implantable-Defibrillator Shocks by Treatment with Sotalol (The New England Journal of Medicine, 1999)
-
Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O
-
InChIKeyZBMZVLHSJCTVON-UHFFFAOYSA-N
- Pubchem - sotalol
- Wikipedia - sotalol
Sotalol is a medication used to treat abnormal heart rhythms. The U.S. Food and Drug Administration (FDA) advises that sotalol only be used for serious abnormal heart rhythms, because its prolongation of the QT interval carries a small risk of life-threatening polymorphic ventricular tachycardia known as torsade de pointes.
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Alternate Names
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Synthesis
Methanesulfonyl chloride
+
Reactant
(Sulfonamide)
Reactant
+
ISOPROPYLAMINE
(Reductive amination)
Reactant
+
2-CHLOROPROPANE
(Alkylation of primary amines)
N-Phenylmethanesulfonamide
+
Reactant
(Friedel-Crafts alkylation)
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