| Weight | 209.318 g/mol |
|---|---|
| Formula | C10H15N3S |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 1 |
| Aromatic Rings | 1 |
| Rotatable Bonds | 2 |
Talipexole (101626-70-4)
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- Protective Effects of the Antiparkinsonian Drugs Talipexole and Pramipexole against 1-Methyl-4-phenylpyridinium-Induced Apoptotic Death in Human Neuroblastoma SH-SY5Y Cells (Molecular Pharmacology, 1998)
- Release and aggregation of cytochrome c and -synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole (European Journal of Pharmacology, 2001)
- INHIBITORY EFFECTS OF TALIPEXOLE AND PRAMIPEXOLE ON MPTP-INDUCED DOPAMINE REDUCTION IN THE STRIATUM OF C57BL/6N MICE (Japanese Journal of Pharmacology, 1997)
- Increase of Bcl-2 protein in neuronal dendritic processes of cerebral cortex and hippocampus by the antiparkinsonian drugs, talipexole and pramipexole (Brain Research, 2000)
- Piribedil Enhances Frontocortical and Hippocampal Release of Acetylcholine in Freely Moving Rats by Blockade of 2A-Adrenoceptors: A Dialysis Comparison to Talipexole and Quinelorane in the Absence of Acetylcholinesterase Inhibitors (Journal of Pharmacology and Experimental Therapeutics, 2003)
- Talipexole and adult Gilles de la tourette's syndrome: Doubleblind, placebocontrolled clinical trial (Movement Disorders, 1994)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESC=CCN1CCC2=C(CC1)SC(=N2)N
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InChIKeyDHSSDEDRBUKTQY-UHFFFAOYSA-N
- Pubchem - Talipexole
- Wikipedia - talipexole
Talipexole (B-HT920, Domnin) is a dopamine agonist that is marketed as a treatment for Parkinson's Disease in Japan by Boehringer Ingelheim; it was introduced in 1996. As of December 2014 it was not approved for marketing in the US nor in Europe. Talipexole is a D2 dopamine receptor agonist and interacts both pre- and post-synaptic receptors.
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Talipexole
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