| Weight | 327.424 g/mol |
|---|---|
| Formula | C20H25NO3 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 4 |
Traxoprodil (134234-12-1)
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- Sigma-Aldrich - Traxoprodil90.90 - 385.00 USD
- Fisher Scientific - Search for Traxoprodil
- TCI - Search for Traxoprodil
- The effect of the selective NMDA receptor antagonist traxoprodil in the treatment of traumatic brain injury. (Journal of Neurotrauma, 2005)
- Metabolism, pharmacokinetics, and excretion of a highly selective N-methyl-D-aspartate receptor antagonist, traxoprodil, in human cytochrome P450 2D6 extensive and poor metabolizers. (Drug Metabolism and Disposition, 2003)
- Metabolism, distribution and excretion of a selective N-methyl-D-aspartate receptor antagonist, traxoprodil, in rats and dogs. (Drug Metabolism and Disposition, 2007)
- Traxoprodil decreases pentylenetetrazol-induced seizures. (Epilepsy Research, 2012)
- Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice. (Metabolic Brain Disease, 2016)
- Traxoprodil augments the antidepressant-like activity of agomelatine but not of mianserin or tianeptine in the forced swim test in mice (Pharmacological Reports, 2016)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)(C3=CC=CC=C3)O
-
InChIKeyQEMSVZNTSXPFJA-UHFFFAOYSA-N
- Pubchem - Traxoprodil
- Wikipedia - traxoprodil
Traxoprodil (developmental code name CP-101606) is a drug developed by Pfizer which acts as an NMDA antagonist, selective for the NR2B subunit. It has neuroprotective, analgesic, and anti-Parkinsonian effects in animal studies. Traxoprodil has been researched in humans as a potential treatment to lessen the damage to the brain after stroke, but results from clinical trials showed only modest benefit.
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