Weight | 505.637 g/mol |
---|---|
Formula | C25H35N3O6S |
Hydrogen Acceptors | 7 |
Hydrogen Donors | 3 |
Aromatic Rings | 2 |
Rotatable Bonds | 11 |
amprenavir (161814-49-9)
Score:
#9 in Virology
,
#137 in Microbiology
,
#1447 in Biology
,
#1695 in Chemistry
"What do you need help with?"
LabBot
- re and siFaceSelective Nitroaldol Reactions Catalyzed by a Rigid Chiral Quaternary Ammonium Salt: A Highly Stereoselective Synthesis of the HIV Protease Inhibitor Amprenavir (Vertex 478) (Angewandte Chemie, 1999)
- Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor. (Pharmaceutical Research, 1999)
- Molecular Dynamics and Free Energy Studies on the Wild-type and Double Mutant HIV-1 Protease Complexed with Amprenavir and Two Amprenavir-Related Inhibitors: Mechanism for Binding and Drug Resistance (Journal of Medicinal Chemistry, 2007)
- Changes in human immunodeficiency virus type 1 Gag at positions L449 and P453 are linked to I50V protease mutants in vivo and cause reduction of sensitivity to amprenavir and improved viral fitness in vitro. (Journal of Virology, 2002)
- Simultaneous determination of the HIV drugs indinavir, amprenavir, saquinavir, ritonavir, lopinavir, nelfinavir, the nelfinavir hydroxymetabolite M8, and nevirapine in human plasma by reversed-phase high-performance liquid chromatography. (Therapeutic Drug Monitoring, 2003)
- Prospective, Intensive Study of Metabolic Changes Associated with 48 Weeks of Amprenavir-Based Antiretroviral Therapy (Clinical Infectious Diseases, 2002)
-
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. -
SMILESCC(C)CN(CC(C(CC1=CC=CC=C1)NC(=O)OC2CCOC2)O)S(=O)(=O)C3=CC=C(C=C3)N
-
InChIKeyYMARZQAQMVYCKC-UHFFFAOYSA-N
- Pubchem - amprenavir
- Wikipedia - amprenavir
Amprenavir (original brand name Agenerase, GlaxoSmithKline) is a protease inhibitor used to treat HIV infection. It was approved by the Food and Drug Administration on April 15, 1999, for twice-a-day dosing instead of needing to be taken every eight hours. The convenient dosing came at a price, as the dose required is 1,200mg, delivered in 8 (eight) very large 150 mg gel capsules or 24 (twenty-four) 50 mg gel capsules twice daily.
Suppliers
Most-cited Publications
Areas of Application
Safety
Alternate Names
External Links
Synthesis
Reactant
+
NUMJNKDUHFCFJO-UHFFFAOYSA-N
(Schotten-Baumann amide from acid)
Reactant
+
4-amino-N-isobutylbenzenesulfonamide
(Chan-Lam coupling reaction)
Similar Compounds
Fosamprenavir calcium
(226700-81-8)
1 alternate name
3 suppliers
OCHRATOXIN C
(4865-85-4)
1 alternate name
3 suppliers
temocapril hydrochloride
(111902-57-9, 110221-44-8)
1 alternate name
3 suppliers
sulfaquinoxaline
(59-40-5)
1 alternate name
3 suppliers
56803-37-3
(83242-23-3, 56803-37-3)
1 alternate name
3 suppliers
BENPERIDOL
(2062-84-2)
1 alternate name
3 suppliers
Trifluperidol
(749-13-3)
1 alternate name
3 suppliers
fenvalerate
(51630-58-1, 66267-77-4, 67614-33-9, 67614-32-8)
1 alternate name
4 safety hazards
3 suppliers
Leu-enkephalin
(14-18-6, 58822-25-6, 59141-40-1)
1 alternate name
3 suppliers
LORCAINIDE
(59729-31-6)
1 alternate name
3 suppliers
Fenpyroximate
(111812-58-9)
1 alternate name
3 suppliers
Halofenozide
(112226-61-6)
1 alternate name
1 safety hazard
3 suppliers
o-Isopropylphenyl diphenyl phosphate
(93925-53-2, 64532-94-1)
1 alternate name
3 suppliers
DISOPYRAMIDE PHOSPHATE
(22059-60-5)
1 alternate name
3 suppliers
LEVOCABASTINE HYDROCHLORIDE
(79547-78-7)
1 alternate name
3 suppliers
rebamipide
(90098-04-7)
1 alternate name
3 suppliers
resmethrin
(35764-59-1, 10453-86-8, 3690-58-2, 28434-01-7)
1 alternate name
4 safety hazards
3 suppliers
Fenazaquin
(120928-09-8)
1 alternate name
3 safety hazards
3 suppliers
Totm
(3319-31-1, 82643-26-3)
1 alternate name
3 suppliers
3319-31-1
(3319-31-1)
1 alternate name
3 suppliers
3319-31-1
(3319-31-1)
1 alternate name
3 suppliers
3319-31-1
(3319-31-1)
1 alternate name
3 suppliers
3319-31-1
(3319-31-1)
1 alternate name
3 suppliers
Narilet
(60205-81-4)
1 alternate name
3 suppliers
LOFEPRAMINE
(23047-25-8)
1 alternate name
3 suppliers
ipratropium
(60205-81-4)
1 alternate name
3 suppliers
BIORESMETHRIN
(10453-55-1, 28434-01-7)
1 alternate name
5 safety hazards
3 suppliers
PHENIRAMINE MALEATE
(132-20-7)
1 alternate name
3 suppliers
Sulfisoxazole acetyl
(80-74-0)
1 alternate name
3 suppliers
Proadifen hydrochloride
(62-68-0)
1 alternate name
3 suppliers
27955-94-8
(27955-94-8)
1 alternate name
3 safety hazards
3 suppliers
Bitertanol
(55179-31-2)
1 alternate name
2 safety hazards
3 suppliers
succinylsulfathiazole
(116-43-8)
1 alternate name
3 suppliers
2618-77-1
(2618-77-1)
1 alternate name
3 suppliers
Mefenacet
(73250-68-7)
1 alternate name
3 safety hazards
3 suppliers
phenothrin
(26002-80-2)
1 alternate name
3 suppliers
D-Phenothrin
(26046-85-5, 26002-80-2)
1 alternate name
3 suppliers
TRI-P-CRESYL PHOSPHATE
(78-32-0, 1330-78-5)
1 alternate name
3 safety hazards
3 suppliers
Enalapril maleate
(75847-73-3, 76095-16-4, 76420-75-2)
1 alternate name
3 suppliers
FLUCYTHRINATE
(70124-77-5)
1 alternate name
3 suppliers
Fentin acetate
(900-45-8, 900-95-8)
1 alternate name
8 safety hazards
3 suppliers
Brilliant Green cation
(18198-35-1)
1 alternate name
3 suppliers
Pararosaniline
(479-73-2)
1 alternate name
3 suppliers
Tris(4-isopropylphenyl) phosphate
(2502-15-0, 68937-41-7, 26967-76-0)
1 alternate name
3 suppliers
Diethylene glycol dibenzoate
(120-55-8)
1 alternate name
3 suppliers
CAS Directory