| Weight | 404.422 g/mol |
|---|---|
| Formula | C23H20N2O5 |
| Hydrogen Acceptors | 4 |
| Hydrogen Donors | 4 |
| Aromatic Rings | 3 |
| Rotatable Bonds | 7 |
bentiromide (37106-97-1)
N-benzoyl-L-tyrosyl-p-aminobenzoic acid · benzoyl-tyrosyl-PABA · PABA-peptide
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- N-benzoyl-l-tyrosyl-p-aminobenzoic acid hydrolase: A metalloendopeptidase of the human intestinal microvillus membrane which degrades biologically active peptides (Archives of Biochemistry and Biophysics, 1988)
- Non-Pancreatic Hydrolysis of N-Benzoyl-l-Tyrosyl-p-Aminobenzoic Acid (PABA-peptide) in the Human Small Intestine (Clinical Science, 1982)
- Bentiromide as a test of exocrine pancreatic function in adult patients with pancreatic exocrine insufficiency: Determination of appropriate dose and urinary collection interval (Gastroenterology, 1983)
- Diagnosis of exocrine pancreatic insufficiency in cystic fibrosis by the synthetic peptide N-benzoyl-l-tyrosyl-p-aminobenzoic acid* (The Journal of Pediatrics, 1978)
- Assessment of exocrine pancreatic function by oral administration of N-benzoyl-L-tyrosyl-p-aminobenzoic acid (Bentiromide): 5 years' clinical experience. (British Journal of Surgery, 1981)
- Biosynthesis of N-benzoyl-l-tyrosyl-p-aminobenzoic acid hydrolase: Disulfide-linked dimers are formed at the site of synthesis in the rough endoplasmic reticulum (Archives of Biochemistry and Biophysics, 1988)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - N-benzoyl-L-tyrosyl-p-aminobenzoic acid
- benzoyl-tyrosyl-PABA
- PABA-peptide
- N-benzoyl-L-tyrosyl-PABA
-
SMILESC1=CC=C(C=C1)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3=CC=C(C=C3)C(=O)O
-
InChIKeySPPTWHFVYKCNNK-UHFFFAOYSA-N
- Pubchem - bentiromide
- Wikipedia - bentiromide
Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas.
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Synthesis
Reactant
+
4-aminobenzoic acid
(Schotten-Baumann amide from acid)
Phenol
+
Reactant
(Friedel-Crafts alkylation)
Benzamide
+
Reactant
(Alkylation of primary amines)
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