bezafibrate (41859-67-0)

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Suppliers

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  1 mg
  $125.00

  10 mg
  $1000.00

  50 mg
  $45.00

  500 mg
  $47.00

  1 g
  $50.00

Most-cited Publications

• Angiographic assessment of effects of bezafibrate on progression of coronary artery disease in young male postinfarction patients. (The Lancet, 1996)
• Bezafibrate for the secondary prevention of myocardial infarction in patients with metabolic syndrome. (JAMA Internal Medicine, 2005)
• Abnormalities in very low, low and high density lipoproteins in hypertriglyceridemia. Reversal toward normal with bezafibrate treatment. (Journal of Clinical Investigation, 1984)
• Cardiovascular Outcomes in Type 2 Diabetes: A double-blind placebo-controlled study of bezafibrate: the St. Mary's, Ealing, Northwick Park Diabetes Cardiovascular Disease Prevention (SENDCAP) Study (Diabetes Care, 1998)
• Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate. (Clinical Pharmacology & Therapeutics, 2001)
• Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPAR agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet (European Journal of Pharmacology, 2006)

Areas of Application

Safety

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Trends

Alternate Names

• Cedur
• BM15.075
• Regadrin B
• Bfizal
• Beza Lande
• Befibrat
• Bezacur
• Beza Puren
• BezaLande
• BM 15.075
• Eulitop
• Solibay
• Lipox
• Bezabeta
• Difaterol
• Bezafibrat PB
• Azufibrat
• Bezamerck
• BezaPuren
• Sklerofibrat
• Bezafisal
• Reducterol
• durabezur
• Beza-Puren
• Bezalip
• BM-15.075
• Beza-Lande
• SMILES
  CC(C)(C(=O)O)OC1=CC=C(C=C1)CCNC(=O)C2=CC=C(C=C2)Cl
• InChIKey
  IIBYAHWJQTYFKB-UHFFFAOYSA-N

External Links

• Pubchem - bezafibrate
• Wikipedia - bezafibrate
  Bezafibrate (marketed as Bezalip and various other brand names) is a fibrate drug used as a lipid-lowering agent to treat hyperlipidaemia. It helps to lower LDL cholesterol and triglyceride in the blood, and increase HDL.

Synthesis

4-CHLOROBENZOYL CHLORIDE  +  Propanoic acid, 2-[4-(2-aminoethyl)phenoxy]-2-methyl- (Schotten-Baumann amide from acid)

2-methyl-2-phenoxypropanoic acid  +  4-chloro-n-(2-chloroethyl)benzamide (Friedel-Crafts alkylation)

4-CHLOROBENZAMIDE  +  Reactant (Alkylation of primary amines)

Synthesis of bezafibrate ›

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