| Weight | 494.013 g/mol |
|---|---|
| Formula | C23H28ClN3O5S |
| Hydrogen Acceptors | 5 |
| Hydrogen Donors | 3 |
| Aromatic Rings | 2 |
| Rotatable Bonds | 8 |
glyburide (10238-21-8)
Glibenclamide · Micronase · Diabeta
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- Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. (The New England Journal of Medicine, 2006)
- A comparison of glyburide and insulin in women with gestational diabetes mellitus. (The New England Journal of Medicine, 2000)
- Ischemic preconditioning during coronary angioplasty is prevented by glibenclamide, a selective ATP-sensitive K+ channel blocker. (Circulation, 1994)
- Morphine Mimics the Cardioprotective Effect of Ischemic Preconditioning via a Glibenclamide-Sensitive Mechanism in the Rat Heart (Circulation Research, 1996)
- Glyburide inhibits the Cryopyrin/Nalp3 inflammasome (Journal of Cell Biology, 2009)
- Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide. (Current Medical Research and Opinion, 2009)
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Predict GHS Hazards for Any Chemical in silico.
Including Acute Oral Tox, Skin Sensitization, Eye Irritation, Aquatic Tox, & more. - Glibenclamide
- Micronase
- Diabeta
- Daonil
- HB419
- HB420
- Euglucon N
- Neogluconin
- HB-419
- HB 420
- Euglucon 5
- Glybenclamide
- HB-420
- HB 419
- Maninil
-
SMILESCOC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
-
InChIKeyZNNLBTZKUZBEKO-UHFFFAOYSA-N
- Pubchem - glyburide
- Wikipedia - glyburide
Glibenclamide, also known as glyburide, is an antidiabetic drug in a class of medications known as sulfonylureas, closely related to sulfonamide antibiotics. It was developed in 1966 in a cooperative study between Boehringer Mannheim (now part of Roche) and Hoechst (now part of Sanofi-Aventis).
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Synthesis
5-chloro-2-methoxybenzamide
+
Reactant
(Alkylation of primary amines)
Reactant
+
CYCLOHEXYLAMINE
(Thiourea)
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glyburide
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